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• W2043803977 abstract "We examined the effects on astrocytes of ACTH, which is used to treat West syndrome. We stimulated cultured rat astrocytes with ACTH1–24, corticotropin-releasing factor, and dexamethasone, and examined changes in neurotrophic factor mRNAs by reverse transcription-PCR. Down-regulation of ciliary neurotrophic factor mRNA expression was observed by stimulation with ACTH1–24, but the expression of nerve growth factor, brain-derived neurotrophic factor, and nerotrophin-3 mRNAs was unaffected. Northern blot analysis revealed that the decrease in ciliary neurotrophic factor mRNA occurred 4 h after stimulation with more than 10 nM of ACTH1–24. Up-regulation of nerotrophin-3 mRNA expression was found after stimulation with 1 mM dexamethasone. These results suggest that ACTH1–24 administrated in West syndrome may influence the expression of neurotrophic factors in astrocytes in vivo." @default.
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• W2043803977 date "2002-12-01" @default.
• W2043803977 modified "2023-10-01" @default.
• W2043803977 title "ACTH1–24 Down-Regulates Expression of Ciliary Neurotrophic Factor mRNA in Cultured Rat Astrocyte" @default.
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• W2043803977 doi "https://doi.org/10.1203/00006450-200212000-00022" @default.
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