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- W2043808540 abstract "Analysis of urinary metabolites of [6,7-3H]-estrone and of [6,7-3H]-estrone-3-glucosiduronate was performed in intact guinea-pigs. The preliminary separation of urinary metabolites was carried out by submitting these metabolites to countercurrent distribution. The further separation of each fraction thus obtained was achieved by means of DEAE-Sephadex A-25 column chromatography. The separated peak was then hydrolyzed with the enzyme and the free steroid released was identified by reverse isotope dilution. Thus, both estrone-3-glucosiduronate and 17β-estradiol-3-glucosiduronate were identified as major urinary metabolites of estrone and of estrone-3-glucosiduronate. Concomitant studies in vitro with homogenates of the kidney, small intestine and liver showed that the small intestine and liver readily conjugated estrone as glucosiduronates and the kidney was a rather poor conjugating organ. The kidney and liver were capable of forming estrone-3-glucosiduronate as well as 17β-estradiol-3-glucosiduronate, whereas estrone-3-glucosiduronate was the only glucosiduronate formed by the small intestine. From these results, it was concluded that in this species not only the liver but the small intestine and kidney participated in the metabolic conjugation of estrone and that a part of estrone-3-glucosiduronate was converted to 17β-estradiol-3-glucosiduronate extrahepatically at least in the kidney." @default.
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- W2043808540 date "1980-08-01" @default.
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- W2043808540 title "The metabolism of estrone and estrone-3-glucosiduronate in the guinea-pig" @default.
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- W2043808540 doi "https://doi.org/10.1016/0022-4731(80)90166-1" @default.
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