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- W2043809550 abstract "Drosophila eggshells display remarkable morphological diversity among species; however, the molecular origin of this structural diversification is mostly unknown. Here, we analyzed the dorsal ridge (DR), a lumen-like structure along the dorsal side of eggshells, from numerous Drosophila species. This structure varies in length and width across species, and is absent from D. melanogaster eggshells. We associated DR formation with distinct spatiotemporal changes in epidermal growth factor receptor (EGFR) activation, which acts as a key receptor in eggshell patterning. We show that changes in the distribution of the TGFα-like ligand Gurken (GRK), a crucial ligand for axis formation, underlies EGFR activation and DR formation in D. willistoni. Furthermore, we demonstrate that GRK from D. willistoni rescues a grk-null D. melanogaster fly and, remarkably, it is also sufficient to generate a DR-like structure on its eggshell." @default.
- W2043809550 created "2016-06-24" @default.
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- W2043809550 date "2014-12-15" @default.
- W2043809550 modified "2023-10-11" @default.
- W2043809550 title "Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from <i>Drosophila</i> species" @default.
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- W2043809550 doi "https://doi.org/10.1242/dev.111898" @default.
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