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- W2043813273 abstract "A variety of spectroscopic and biochemical studies of the photoreceptor rhodopsin have revealed conformation changes which occur upon its photoactivation. Assignment of these molecular alterations to specific regions in the receptor has been attempted by studying native opsin regenerated with synthetic retinal analogs or recombinant opsins regenerated with 11-cis retinal. We propose a model for the photoactivation mechanism which defines 'off' and 'on' states for individual molecular groups. These groups have been identified to undergo structural alterations during photoactivation. Analysis of mutant pigments in which specific groups are locked into their respective 'on' or 'off' states provides a framework to identify determinants of the active conformation as well as the minimal number of intramolecular transitions to switch to this conformation. The simple model proposed for the active-state of rhodopsin can be compared to structural models of its ground-state to localize chromophore-protein interactions that may be important in the photoactivation mechanism." @default.
- W2043813273 created "2016-06-24" @default.
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- W2043813273 date "1995-09-01" @default.
- W2043813273 modified "2023-10-13" @default.
- W2043813273 title "Photoactivated state of rhodopsin and how it can form" @default.
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- W2043813273 doi "https://doi.org/10.1016/0301-4622(95)00030-2" @default.
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