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• W2043816064 abstract "1. The effect of extracellularly applied pentachlorophenol (PCP) was studied on the membrane potential (Vm) and Ca2+ uptake in isolated single skeletal muscle cells of Balanus nubilus. 2. When compared with the controls, 0.1 mM PCP induced a significant (P < 0.05) increase in Ca2+ uptake accompanied by membrane depolarization (9 mV at 45 min incubation). This depolarization was reduced by 11% of extracellular Ca2+ (Cao2+) was replaced by Tris+ and by 50% if extracellular Na+ was also replaced by Tris+. 3. The Ca2+ channel blocker, verapamil (0.1 mM), completely inhibited the PCP-induced Ca2+ uptake as well as the membrane depolarization either in the absence or presence of Cao2+. Experiments on voltage-clamped cells show that the PCP-induced Ca2+ uptake was independent of the PCP-induced depolarization. 4. The results indicate that PCP induces activation of a verapamil-sensitive Ca2+ influx pathway (presumably L-type Ca2+ channels) independent of Vm. The permeation of Ca2+, Na+ and Tris+ through this pathway produces membrane depolarization in the following order of effectiveness: Ca2+ > Na+ > Tris+." @default.
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• W2043816064 date "1996-02-15" @default.
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• W2043816064 title "Effect of pentachlorophenol on calcium accumulation in barnacle muscle cells." @default.
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• W2043816064 doi "https://doi.org/10.1113/jphysiol.1996.sp021192" @default.
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