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- W2043824897 abstract "Background and purpose Cerebral microbleeds ( CMB s) have been extensively studied in healthy controls and patients with cerebrovascular disease and A lzheimer's disease. Our aim was to characterize the clinical and radiological features of CMB s in idiopathic P arkinson's disease ( IPD ). Methods This cross‐sectional study included consecutive parkinsonian patients who attended the authors' movement disorders clinic from M arch 2010 to F ebruary 2012 and underwent a standard magnetic resonance imaging ( MRI ) protocol with gradient recalled echo taken with a 3 T MRI machine. Results Amongst parkinsonian disorders, CMB s were most common in vascular parkinsonism ( VP ) (56%) and least common in IPD (17.7%). In IPD , CMB s were significantly associated with white matter hyperintensities and concurrent lacunar infarctions. The presence of CMB s had no effect on various cognitive domains in IPD . IPD with CMB s was discriminated from VP by clinical and neuroimaging findings: frequencies of motor subtypes were similar between IPD with and without CMB s, whereas all VP patients were the postural‐instability gait difficulty type. In 90.9% of the IPD cases with CMB s, the numbers of CMB s were three or less, whereas the numbers of CMB s exceeded three in 50% of the cases of VP and exceeded 10 in 31.3% of the cases ( P < 0.001). The topography of the CMB s in IPD was also different from that in VP ( P < 0.01). Conclusions Cerebral microbleeds are not rare in IPD , and IPD with CMB s does not appear to be a form of VP . Further studies in larger populations are needed to elucidate the clinical implications of CMB s in terms of prognoses and cognitive changes in IPD ." @default.
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- W2043824897 date "2014-11-04" @default.
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- W2043824897 title "Characterization of cerebral microbleeds in idiopathic Parkinson's disease" @default.
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- W2043824897 doi "https://doi.org/10.1111/ene.12584" @default.
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