FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043827794> ?p ?o ?g. }

• W2043827794 endingPage "e44730" @default.
• W2043827794 startingPage "e44730" @default.
• W2043827794 abstract "Haemophilus influenzae (Hi) colonizes the human respiratory tract and is an important pathogen associated with chronic obstructive pulmonary disease (COPD). Bacterial factors that interact with the human host may be important in the pathogenesis of COPD. These factors, however, have not been well defined. The overall goal of this study was to identify bacterial genetic elements with increased prevalence among H. influenzae strains isolated from patients with COPD compared to those isolated from the pharynges of healthy individuals.Four nontypeable H. influenzae (NTHi) strains, two isolated from the airways of patients with COPD and two from a healthy individual, were subjected to whole genome sequencing using 454 FLX Titanium technology. COPD strain-specific genetic islands greater than 500 bp in size were identified by in silico subtraction. Open reading frames residing within these islands include known Hi virulence genes such as lic2b, hgbA, iga, hmw1 and hmw2, as well as genes encoding urease and other enzymes involving metabolic pathways. The distributions of seven selected genetic islands were assessed among a panel of 421 NTHi strains of both disease and commensal origins using a Library-on-a-Slide high throughput dot blot DNA hybridization procedure. Four of the seven islands screened, containing genes that encode a methyltransferase, a dehydrogenase, a urease synthesis enzyme, and a set of unknown short ORFs, respectively, were more prevalent in COPD strains than in colonizing strains with prevalence ratios ranging from 1.21 to 2.85 (p ≤ 0.0002). Surprisingly, none of these sequences show increased prevalence among NTHi isolated from the airways of patients with cystic fibrosis.Our data suggest that specific bacterial genes, many involved in metabolic functions, are associated with the ability of NTHi strains to survive in the lower airways of patients with COPD." @default.
• W2043827794 created "2016-06-24" @default.
• W2043827794 creator A5011312451 @default.
• W2043827794 creator A5022145907 @default.
• W2043827794 creator A5034990894 @default.
• W2043827794 creator A5035168217 @default.
• W2043827794 creator A5049990994 @default.
• W2043827794 creator A5050581245 @default.
• W2043827794 creator A5055181090 @default.
• W2043827794 creator A5058808571 @default.
• W2043827794 creator A5059208271 @default.
• W2043827794 creator A5067939471 @default.
• W2043827794 creator A5072361619 @default.
• W2043827794 date "2012-09-06" @default.
• W2043827794 modified "2023-10-12" @default.
• W2043827794 title "Nontypeable Haemophilus influenzae Genetic Islands Associated with Chronic Pulmonary Infection" @default.
• W2043827794 cites W1828665176 @default.
• W2043827794 cites W1947935290 @default.
• W2043827794 cites W1966572047 @default.
• W2043827794 cites W1966796134 @default.
• W2043827794 cites W1972016629 @default.
• W2043827794 cites W1977497036 @default.
• W2043827794 cites W1984741582 @default.
• W2043827794 cites W1987261946 @default.
• W2043827794 cites W1998977561 @default.
• W2043827794 cites W2002900443 @default.
• W2043827794 cites W2004406329 @default.
• W2043827794 cites W2008834496 @default.
• W2043827794 cites W2011609238 @default.
• W2043827794 cites W2015327085 @default.
• W2043827794 cites W2022413541 @default.
• W2043827794 cites W2022467415 @default.
• W2043827794 cites W2034923942 @default.
• W2043827794 cites W2035643252 @default.
• W2043827794 cites W2041257508 @default.
• W2043827794 cites W2055043387 @default.
• W2043827794 cites W2055062822 @default.
• W2043827794 cites W2055620515 @default.
• W2043827794 cites W2056335097 @default.
• W2043827794 cites W2058477464 @default.
• W2043827794 cites W2073550973 @default.
• W2043827794 cites W2074612698 @default.
• W2043827794 cites W2081360802 @default.
• W2043827794 cites W2083461264 @default.
• W2043827794 cites W2083636197 @default.
• W2043827794 cites W2086062913 @default.
• W2043827794 cites W2090110893 @default.
• W2043827794 cites W2095929456 @default.
• W2043827794 cites W2097053877 @default.
• W2043827794 cites W2097511111 @default.
• W2043827794 cites W2098666638 @default.
• W2043827794 cites W2099109562 @default.
• W2043827794 cites W2099718986 @default.
• W2043827794 cites W2100071542 @default.
• W2043827794 cites W2100287445 @default.
• W2043827794 cites W2103467464 @default.
• W2043827794 cites W2109628984 @default.
• W2043827794 cites W2110065044 @default.
• W2043827794 cites W2114060217 @default.
• W2043827794 cites W2114746383 @default.
• W2043827794 cites W2120649655 @default.
• W2043827794 cites W2130911505 @default.
• W2043827794 cites W2131164917 @default.
• W2043827794 cites W2144682743 @default.
• W2043827794 cites W2150709792 @default.
• W2043827794 cites W2151020563 @default.
• W2043827794 cites W2151209984 @default.
• W2043827794 cites W2152793666 @default.
• W2043827794 cites W2153798763 @default.
• W2043827794 cites W2157173569 @default.
• W2043827794 cites W2162881990 @default.
• W2043827794 cites W2163408209 @default.
• W2043827794 cites W2165636980 @default.
• W2043827794 cites W2166666507 @default.
• W2043827794 cites W2259719930 @default.
• W2043827794 cites W2411476636 @default.
• W2043827794 cites W3160394654 @default.
• W2043827794 cites W2917647036 @default.
• W2043827794 doi "https://doi.org/10.1371/journal.pone.0044730" @default.
• W2043827794 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3435294" @default.
• W2043827794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22970300" @default.
• W2043827794 hasPublicationYear "2012" @default.
• W2043827794 type Work @default.
• W2043827794 sameAs 2043827794 @default.
• W2043827794 citedByCount "25" @default.
• W2043827794 countsByYear W20438277942012 @default.
• W2043827794 countsByYear W20438277942013 @default.
• W2043827794 countsByYear W20438277942014 @default.
• W2043827794 countsByYear W20438277942015 @default.
• W2043827794 countsByYear W20438277942016 @default.
• W2043827794 countsByYear W20438277942017 @default.
• W2043827794 countsByYear W20438277942018 @default.
• W2043827794 countsByYear W20438277942019 @default.
• W2043827794 countsByYear W20438277942020 @default.
• W2043827794 countsByYear W20438277942021 @default.
• W2043827794 countsByYear W20438277942022 @default.
• W2043827794 countsByYear W20438277942023 @default.
• W2043827794 crossrefType "journal-article" @default.

• next