Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043842975> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2043842975 endingPage "85" @default.
- W2043842975 startingPage "79" @default.
- W2043842975 abstract "We used 32P-postlabelling to compare DNA binding between the potent hepatocarcinogen 2,6-dinitrotoluene and its noncarcinogenic analog 2,6-diaminotoluene. The two compounds were compared to determine whether differences in DNA binding could partly explain the differences in their carcinogenicity. Fischer-344 rats were administered 1.2 mmol/kg of a compound by single i.p. injection and examined for DNA adduct formation in the liver. Four adducts were detected following administration of 2,6-dinitrotoluene, with a total adduct yield of 13.5 adducted nucleotides per 107 nucleotides. Qualitatively identical adducts were also detected after treatment with the derivative 2-amino-6-nitrotoluene. Adduct yields from 2,6-dinitrotoluene were 30 times greater than from 2-amino-6-nitrotoluene. No adducts were observed following treatment with 2,6-diaminotoluene. 2,6-Dinitrotoluene and 2,6-diaminotoluene were also compared for qualitative differences in hepatotoxicity. 2,6-Dinitrotoluene produced extensive hemorrhagic necrosis in the liver, whereas no evidence of hepatocellular necrosis was detected following administration of the latter. The differences between the two compounds in both DNA binding and cytotoxicity were consistent with the differences in their carcinogenicity." @default.
- W2043842975 created "2016-06-24" @default.
- W2043842975 creator A5023932233 @default.
- W2043842975 creator A5080773176 @default.
- W2043842975 date "1993-02-01" @default.
- W2043842975 modified "2023-10-08" @default.
- W2043842975 title "Comparison of DNA binding between the carcinogen 2,6-dinitrotoluene and its noncarcinogenic analog 2,6-diaminotoluene" @default.
- W2043842975 cites W1968079518 @default.
- W2043842975 cites W1976579003 @default.
- W2043842975 cites W1996911322 @default.
- W2043842975 cites W2000311175 @default.
- W2043842975 cites W2005381573 @default.
- W2043842975 cites W2017299876 @default.
- W2043842975 cites W2020312776 @default.
- W2043842975 cites W2027078480 @default.
- W2043842975 cites W2029370209 @default.
- W2043842975 cites W2055628270 @default.
- W2043842975 cites W2059882890 @default.
- W2043842975 cites W2062534671 @default.
- W2043842975 cites W2082775292 @default.
- W2043842975 cites W2094678835 @default.
- W2043842975 cites W2095469145 @default.
- W2043842975 cites W2116757464 @default.
- W2043842975 cites W2128442121 @default.
- W2043842975 cites W2138757621 @default.
- W2043842975 cites W2142233850 @default.
- W2043842975 cites W2153065586 @default.
- W2043842975 cites W2162143046 @default.
- W2043842975 cites W8347340 @default.
- W2043842975 doi "https://doi.org/10.1016/0165-7992(93)90028-t" @default.
- W2043842975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7678174" @default.
- W2043842975 hasPublicationYear "1993" @default.
- W2043842975 type Work @default.
- W2043842975 sameAs 2043842975 @default.
- W2043842975 citedByCount "23" @default.
- W2043842975 countsByYear W20438429752012 @default.
- W2043842975 countsByYear W20438429752014 @default.
- W2043842975 countsByYear W20438429752015 @default.
- W2043842975 countsByYear W20438429752016 @default.
- W2043842975 countsByYear W20438429752022 @default.
- W2043842975 countsByYear W20438429752023 @default.
- W2043842975 crossrefType "journal-article" @default.
- W2043842975 hasAuthorship W2043842975A5023932233 @default.
- W2043842975 hasAuthorship W2043842975A5080773176 @default.
- W2043842975 hasConcept C104317684 @default.
- W2043842975 hasConcept C108204754 @default.
- W2043842975 hasConcept C114246631 @default.
- W2043842975 hasConcept C153911025 @default.
- W2043842975 hasConcept C178790620 @default.
- W2043842975 hasConcept C185592680 @default.
- W2043842975 hasConcept C2781247443 @default.
- W2043842975 hasConcept C512185932 @default.
- W2043842975 hasConcept C552990157 @default.
- W2043842975 hasConcept C55493867 @default.
- W2043842975 hasConcept C71240020 @default.
- W2043842975 hasConcept C86803240 @default.
- W2043842975 hasConceptScore W2043842975C104317684 @default.
- W2043842975 hasConceptScore W2043842975C108204754 @default.
- W2043842975 hasConceptScore W2043842975C114246631 @default.
- W2043842975 hasConceptScore W2043842975C153911025 @default.
- W2043842975 hasConceptScore W2043842975C178790620 @default.
- W2043842975 hasConceptScore W2043842975C185592680 @default.
- W2043842975 hasConceptScore W2043842975C2781247443 @default.
- W2043842975 hasConceptScore W2043842975C512185932 @default.
- W2043842975 hasConceptScore W2043842975C552990157 @default.
- W2043842975 hasConceptScore W2043842975C55493867 @default.
- W2043842975 hasConceptScore W2043842975C71240020 @default.
- W2043842975 hasConceptScore W2043842975C86803240 @default.
- W2043842975 hasIssue "2" @default.
- W2043842975 hasLocation W20438429751 @default.
- W2043842975 hasLocation W20438429752 @default.
- W2043842975 hasOpenAccess W2043842975 @default.
- W2043842975 hasPrimaryLocation W20438429751 @default.
- W2043842975 hasRelatedWork W1974263506 @default.
- W2043842975 hasRelatedWork W1975102042 @default.
- W2043842975 hasRelatedWork W2001329454 @default.
- W2043842975 hasRelatedWork W2022532929 @default.
- W2043842975 hasRelatedWork W2027941205 @default.
- W2043842975 hasRelatedWork W2030434415 @default.
- W2043842975 hasRelatedWork W2044985636 @default.
- W2043842975 hasRelatedWork W2060591656 @default.
- W2043842975 hasRelatedWork W2071913018 @default.
- W2043842975 hasRelatedWork W2523454193 @default.
- W2043842975 hasVolume "301" @default.
- W2043842975 isParatext "false" @default.
- W2043842975 isRetracted "false" @default.
- W2043842975 magId "2043842975" @default.
- W2043842975 workType "article" @default.