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- W2043844080 abstract "P RESERVATION-REPERFUSION INJURY is one of the most serious problems in liver transplantation. Endothelin-1 (ET-l) is a 21-residue peptide that has various chemical and mechanical factors.’ Recently, various studies have focused on the hepatic microcirculatory disturbance induced by ET-l. 2,3 We reported that ET-l was harmful to the grafted liver, and that levels of ET-l correlated closely with the activity of sinusoidal endothelial cells and with graft survival after reperfusion in porcine orthotopic liver transplants.4 These results suggest that inhibition of endothelin activity might be able to prevent preservation-reperfusion injury in liver transplantation. TAK-044, which is a novel nonselective receptor (ETAIB) antagonist,” has been reported to have a hepatoprotective effect against ischemia-reperfusion injury in warm ischemic models of canine liversh,’ Little is known, however, about the efficacy of this agent on preservation-reperfusion injury in liver transplantation. The aim of the present study is to evaluate the efficacy of TAK-044 in protecting the grafted liver from preservationreperfusion injury during orthotopic liver transplantation in pigs." @default.
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- W2043844080 date "1997-12-01" @default.
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- W2043844080 title "Efficacy of endothelin-1 receptor antagonist for protecting the function of grafted livers from preservation-reperfusion injury in pigs" @default.
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- W2043844080 doi "https://doi.org/10.1016/s0041-1345(97)00981-0" @default.
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