FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043854890> ?p ?o ?g. }

• W2043854890 endingPage "2955" @default.
• W2043854890 startingPage "2946" @default.
• W2043854890 abstract "The main objective of this study was to synthesize novel folic acid-functionalized diblock copolymer micelles and evaluate their solubilization of two poorly water-soluble anti-tumor drugs, tamoxifen and paclitaxel, which suffer from low water solubility and/or poor hydrolytic stability. The diblock copolymer consisted of a permanently hydrophilic block comprising 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) residues and a pH-sensitive hydrophobic block comprising 2-(diisopropylamino)ethyl methacrylate (DPA) residues. Folic acid (FA) was conjugated to the end of the MPC block so that this group was located on the micelle periphery. Tamoxifen- and paclitaxel-loaded micelles were prepared from FA–MPC–DPA copolymers prepared with two different block compositions that were designed to produce optimal solubilization of each drug. Their drug-loading capacities and aqueous stabilities were determined by high performance liquid chromatography. The hydrodynamic diameters of tamoxifen- and paclitaxel-loaded FA–MPC–DPA micelles ranged from 30 to 60 nm, as judged by dynamic light scattering (DLS) and transmission electron microscopy (TEM) studies. Finally, tamoxifen and paclitaxel release profiles were evaluated in phosphate buffer solution at pH 7.4 and 5. These studies demonstrated that FA–MPC–DPA micelles acted as useful drug carriers, leading to relatively slow release of both tamoxifen and paclitaxel into aqueous solution over a period of 7 days. In addition, rapid release can be triggered by lowering the solution pH to 5, which leads to protonation of the DPA block and hence rapid micellar dissociation." @default.
• W2043854890 created "2016-06-24" @default.
• W2043854890 creator A5005052674 @default.
• W2043854890 creator A5011217965 @default.
• W2043854890 creator A5032609290 @default.
• W2043854890 creator A5035155308 @default.
• W2043854890 creator A5040668512 @default.
• W2043854890 creator A5069717843 @default.
• W2043854890 date "2006-04-01" @default.
• W2043854890 modified "2023-10-15" @default.
• W2043854890 title "New folate-functionalized biocompatible block copolymer micelles as potential anti-cancer drug delivery systems" @default.
• W2043854890 cites W1528820340 @default.
• W2043854890 cites W1560482245 @default.
• W2043854890 cites W1594606204 @default.
• W2043854890 cites W1969168513 @default.
• W2043854890 cites W1981534406 @default.
• W2043854890 cites W1981680929 @default.
• W2043854890 cites W1981693314 @default.
• W2043854890 cites W1993776299 @default.
• W2043854890 cites W1995995697 @default.
• W2043854890 cites W1996993465 @default.
• W2043854890 cites W1998575913 @default.
• W2043854890 cites W2002516695 @default.
• W2043854890 cites W2004742967 @default.
• W2043854890 cites W2007996033 @default.
• W2043854890 cites W2008215555 @default.
• W2043854890 cites W2013919931 @default.
• W2043854890 cites W2016548996 @default.
• W2043854890 cites W2032860131 @default.
• W2043854890 cites W2043401514 @default.
• W2043854890 cites W2055483349 @default.
• W2043854890 cites W2073186779 @default.
• W2043854890 cites W2079184456 @default.
• W2043854890 cites W2080464257 @default.
• W2043854890 cites W2081968028 @default.
• W2043854890 cites W2082587127 @default.
• W2043854890 cites W2088905583 @default.
• W2043854890 cites W2090127461 @default.
• W2043854890 cites W2132113260 @default.
• W2043854890 cites W2137192554 @default.
• W2043854890 cites W2138036137 @default.
• W2043854890 cites W2156368993 @default.
• W2043854890 cites W2171384411 @default.
• W2043854890 doi "https://doi.org/10.1016/j.polymer.2006.03.014" @default.
• W2043854890 hasPublicationYear "2006" @default.
• W2043854890 type Work @default.
• W2043854890 sameAs 2043854890 @default.
• W2043854890 citedByCount "110" @default.
• W2043854890 countsByYear W20438548902012 @default.
• W2043854890 countsByYear W20438548902013 @default.
• W2043854890 countsByYear W20438548902014 @default.
• W2043854890 countsByYear W20438548902015 @default.
• W2043854890 countsByYear W20438548902016 @default.
• W2043854890 countsByYear W20438548902017 @default.
• W2043854890 countsByYear W20438548902018 @default.
• W2043854890 countsByYear W20438548902019 @default.
• W2043854890 countsByYear W20438548902020 @default.
• W2043854890 countsByYear W20438548902021 @default.
• W2043854890 countsByYear W20438548902022 @default.
• W2043854890 crossrefType "journal-article" @default.
• W2043854890 hasAuthorship W2043854890A5005052674 @default.
• W2043854890 hasAuthorship W2043854890A5011217965 @default.
• W2043854890 hasAuthorship W2043854890A5032609290 @default.
• W2043854890 hasAuthorship W2043854890A5035155308 @default.
• W2043854890 hasAuthorship W2043854890A5040668512 @default.
• W2043854890 hasAuthorship W2043854890A5069717843 @default.
• W2043854890 hasConcept C11268172 @default.
• W2043854890 hasConcept C132050475 @default.
• W2043854890 hasConcept C141071460 @default.
• W2043854890 hasConcept C14631669 @default.
• W2043854890 hasConcept C155574463 @default.
• W2043854890 hasConcept C155672457 @default.
• W2043854890 hasConcept C15920480 @default.
• W2043854890 hasConcept C171250308 @default.
• W2043854890 hasConcept C178790620 @default.
• W2043854890 hasConcept C184651966 @default.
• W2043854890 hasConcept C185592680 @default.
• W2043854890 hasConcept C188027245 @default.
• W2043854890 hasConcept C192562407 @default.
• W2043854890 hasConcept C2776694085 @default.
• W2043854890 hasConcept C2777292972 @default.
• W2043854890 hasConcept C2779820397 @default.
• W2043854890 hasConcept C521977710 @default.
• W2043854890 hasConcept C71924100 @default.
• W2043854890 hasConceptScore W2043854890C11268172 @default.
• W2043854890 hasConceptScore W2043854890C132050475 @default.
• W2043854890 hasConceptScore W2043854890C141071460 @default.
• W2043854890 hasConceptScore W2043854890C14631669 @default.
• W2043854890 hasConceptScore W2043854890C155574463 @default.
• W2043854890 hasConceptScore W2043854890C155672457 @default.
• W2043854890 hasConceptScore W2043854890C15920480 @default.
• W2043854890 hasConceptScore W2043854890C171250308 @default.
• W2043854890 hasConceptScore W2043854890C178790620 @default.
• W2043854890 hasConceptScore W2043854890C184651966 @default.
• W2043854890 hasConceptScore W2043854890C185592680 @default.
• W2043854890 hasConceptScore W2043854890C188027245 @default.
• W2043854890 hasConceptScore W2043854890C192562407 @default.
• W2043854890 hasConceptScore W2043854890C2776694085 @default.

• next