FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043885237> ?p ?o ?g. }

• W2043885237 endingPage "241" @default.
• W2043885237 startingPage "234" @default.
• W2043885237 abstract "Methamphetamine (METH) is one of the most commonly abused drugs that may result in neurotoxic damage. Many lines of evidence have revealed that oxidative stress plays an important role in METH-induced neurotoxic effects. In a previous study, it was demonstrated in human neuroblastoma SH-SY5Y cells that enhanced oxidative stress was related to METH-induced apoptosis. To evaluate which of the three major mitogen-activated protein (MAP) kinase signaling pathways are involved in the process, namely the extracellular signal-related kinases (ERK), the p38 MAP kinases (p38) and the Jun-N-terminal kinases (JNK), we performed a time-course assessment. This indicated that METH induced an increase in the phosphorylation of ERK and JNK, but not of p38. Moreover, a JNK-specific inhibitor, SP600125, partially but significantly rescued METH-induced cell death, while PD98059 (an ERK kinase inhibitor) and SB203580 (a p38 inhibitor) had no protective effect. We also found that vitamin E (Vit E) prevented METH-induced JNK phosporylation and SP600125 inhibited METH-induced c-Jun phosphorylation. Furthermore, METH-activated caspase-3 activity was significantly repressed by Vit E and in SP600125 treated cells. We suggest that the oxidative stress-activated JNK signaling pathway is involved in METH-induced cell death." @default.
• W2043885237 created "2016-06-24" @default.
• W2043885237 creator A5011337424 @default.
• W2043885237 creator A5022547338 @default.
• W2043885237 creator A5056541353 @default.
• W2043885237 creator A5071126579 @default.
• W2043885237 creator A5081789067 @default.
• W2043885237 date "2008-04-01" @default.
• W2043885237 modified "2023-10-12" @default.
• W2043885237 title "Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells" @default.
• W2043885237 cites W1683600212 @default.
• W2043885237 cites W1969606022 @default.
• W2043885237 cites W1988949532 @default.
• W2043885237 cites W1992675663 @default.
• W2043885237 cites W1993035302 @default.
• W2043885237 cites W2012907539 @default.
• W2043885237 cites W2015913654 @default.
• W2043885237 cites W2017009693 @default.
• W2043885237 cites W2018629380 @default.
• W2043885237 cites W2021479980 @default.
• W2043885237 cites W2022914311 @default.
• W2043885237 cites W2023590101 @default.
• W2043885237 cites W2024468216 @default.
• W2043885237 cites W2034580062 @default.
• W2043885237 cites W2035936653 @default.
• W2043885237 cites W2040123458 @default.
• W2043885237 cites W2043313694 @default.
• W2043885237 cites W2044627978 @default.
• W2043885237 cites W2048570076 @default.
• W2043885237 cites W2050219143 @default.
• W2043885237 cites W2052615494 @default.
• W2043885237 cites W2059962425 @default.
• W2043885237 cites W2061952598 @default.
• W2043885237 cites W2062042157 @default.
• W2043885237 cites W2063702713 @default.
• W2043885237 cites W2068049440 @default.
• W2043885237 cites W2080253613 @default.
• W2043885237 cites W2084240094 @default.
• W2043885237 cites W2093658250 @default.
• W2043885237 cites W2096931514 @default.
• W2043885237 cites W2101190305 @default.
• W2043885237 cites W2119807130 @default.
• W2043885237 cites W2125784520 @default.
• W2043885237 cites W2144326453 @default.
• W2043885237 cites W2150081412 @default.
• W2043885237 cites W2158639431 @default.
• W2043885237 cites W2158722919 @default.
• W2043885237 cites W2162690000 @default.
• W2043885237 cites W2169920915 @default.
• W2043885237 cites W4243541841 @default.
• W2043885237 doi "https://doi.org/10.1016/j.tox.2008.01.020" @default.
• W2043885237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18325654" @default.
• W2043885237 hasPublicationYear "2008" @default.
• W2043885237 type Work @default.
• W2043885237 sameAs 2043885237 @default.
• W2043885237 citedByCount "65" @default.
• W2043885237 countsByYear W20438852372012 @default.
• W2043885237 countsByYear W20438852372013 @default.
• W2043885237 countsByYear W20438852372014 @default.
• W2043885237 countsByYear W20438852372015 @default.
• W2043885237 countsByYear W20438852372016 @default.
• W2043885237 countsByYear W20438852372017 @default.
• W2043885237 countsByYear W20438852372018 @default.
• W2043885237 countsByYear W20438852372019 @default.
• W2043885237 countsByYear W20438852372020 @default.
• W2043885237 countsByYear W20438852372021 @default.
• W2043885237 countsByYear W20438852372023 @default.
• W2043885237 crossrefType "journal-article" @default.
• W2043885237 hasAuthorship W2043885237A5011337424 @default.
• W2043885237 hasAuthorship W2043885237A5022547338 @default.
• W2043885237 hasAuthorship W2043885237A5056541353 @default.
• W2043885237 hasAuthorship W2043885237A5071126579 @default.
• W2043885237 hasAuthorship W2043885237A5081789067 @default.
• W2043885237 hasConcept C11960822 @default.
• W2043885237 hasConcept C132149769 @default.
• W2043885237 hasConcept C166940927 @default.
• W2043885237 hasConcept C178790620 @default.
• W2043885237 hasConcept C184235292 @default.
• W2043885237 hasConcept C185592680 @default.
• W2043885237 hasConcept C190283241 @default.
• W2043885237 hasConcept C2776151105 @default.
• W2043885237 hasConcept C2776715637 @default.
• W2043885237 hasConcept C2779083432 @default.
• W2043885237 hasConcept C2779989194 @default.
• W2043885237 hasConcept C2780114369 @default.
• W2043885237 hasConcept C31573885 @default.
• W2043885237 hasConcept C51551487 @default.
• W2043885237 hasConcept C521977710 @default.
• W2043885237 hasConcept C54355233 @default.
• W2043885237 hasConcept C55493867 @default.
• W2043885237 hasConcept C57074206 @default.
• W2043885237 hasConcept C62478195 @default.
• W2043885237 hasConcept C81885089 @default.
• W2043885237 hasConcept C86803240 @default.
• W2043885237 hasConcept C95444343 @default.
• W2043885237 hasConcept C97029542 @default.
• W2043885237 hasConceptScore W2043885237C11960822 @default.
• W2043885237 hasConceptScore W2043885237C132149769 @default.

• next