FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043886644> ?p ?o ?g. }

• W2043886644 endingPage "665" @default.
• W2043886644 startingPage "657" @default.
• W2043886644 abstract "The evolution of the ribonuclease A (RNase A) vertebrate-specific enzyme family is interesting in that specific gene lineages appear to be responding to unique selective pressures in wildly diverse manners to generate proteins that are capable of reducing the infectivity of viruses, killing systemic pathogens, and inducing the growth of blood vessels all while maintaining the signature motifs of a ribonuclease. In this paper, we present the DNA sequence and gene structure of Mus musculus RNase 6 and examine the expression pattern and enzymatic activity of the recombinant protein. M. musculus RNase 6 has a limited expression pattern compared to human RNase 6 and is an efficient ribonuclease, with a catalytic efficiency 17-fold higher than that of human protein. Evo- lutionary analysis reveals that RNase 6 was subject to unusual evolutionary forces (dN/dS = 1.2) in an ancestral rodent lineage before the separation of Mus and Rattus. However, more recent evolution of rodent RNase 6 has been relatively conserved, with an average dN/dS of 0.66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology." @default.
• W2043886644 created "2016-06-24" @default.
• W2043886644 creator A5020510223 @default.
• W2043886644 creator A5068150354 @default.
• W2043886644 creator A5082143549 @default.
• W2043886644 date "2004-11-01" @default.
• W2043886644 modified "2023-10-16" @default.
• W2043886644 title "Isolation, Characterization, and Evolutionary Divergence of Mouse RNase 6: Evidence for Unusual Evolution in Rodents" @default.
• W2043886644 cites W1558693276 @default.
• W2043886644 cites W1963858560 @default.
• W2043886644 cites W1964547833 @default.
• W2043886644 cites W1971912255 @default.
• W2043886644 cites W1973501200 @default.
• W2043886644 cites W1976900419 @default.
• W2043886644 cites W1984195830 @default.
• W2043886644 cites W1986269363 @default.
• W2043886644 cites W1986763952 @default.
• W2043886644 cites W2001439699 @default.
• W2043886644 cites W2004788054 @default.
• W2043886644 cites W2011193225 @default.
• W2043886644 cites W2013025204 @default.
• W2043886644 cites W2018031095 @default.
• W2043886644 cites W2019046938 @default.
• W2043886644 cites W2030966943 @default.
• W2043886644 cites W2035611907 @default.
• W2043886644 cites W2045741895 @default.
• W2043886644 cites W2058795503 @default.
• W2043886644 cites W2062135679 @default.
• W2043886644 cites W2062377208 @default.
• W2043886644 cites W2065461553 @default.
• W2043886644 cites W2066013154 @default.
• W2043886644 cites W2068366313 @default.
• W2043886644 cites W2095267936 @default.
• W2043886644 cites W2097382368 @default.
• W2043886644 cites W2097706568 @default.
• W2043886644 cites W2101671848 @default.
• W2043886644 cites W2104253471 @default.
• W2043886644 cites W2124684051 @default.
• W2043886644 cites W2130710443 @default.
• W2043886644 cites W2133104753 @default.
• W2043886644 cites W2141934994 @default.
• W2043886644 cites W2148252006 @default.
• W2043886644 cites W2150365288 @default.
• W2043886644 cites W2150522429 @default.
• W2043886644 cites W2151303693 @default.
• W2043886644 cites W2156434383 @default.
• W2043886644 cites W2157847015 @default.
• W2043886644 cites W2164947929 @default.
• W2043886644 cites W2168909179 @default.
• W2043886644 cites W4252119955 @default.
• W2043886644 doi "https://doi.org/10.1007/s00239-004-2657-0" @default.
• W2043886644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15693621" @default.
• W2043886644 hasPublicationYear "2004" @default.
• W2043886644 type Work @default.
• W2043886644 sameAs 2043886644 @default.
• W2043886644 citedByCount "14" @default.
• W2043886644 countsByYear W20438866442012 @default.
• W2043886644 countsByYear W20438866442015 @default.
• W2043886644 countsByYear W20438866442016 @default.
• W2043886644 countsByYear W20438866442018 @default.
• W2043886644 countsByYear W20438866442019 @default.
• W2043886644 countsByYear W20438866442021 @default.
• W2043886644 crossrefType "journal-article" @default.
• W2043886644 hasAuthorship W2043886644A5020510223 @default.
• W2043886644 hasAuthorship W2043886644A5068150354 @default.
• W2043886644 hasAuthorship W2043886644A5082143549 @default.
• W2043886644 hasBestOaLocation W20438866442 @default.
• W2043886644 hasConcept C104317684 @default.
• W2043886644 hasConcept C10879258 @default.
• W2043886644 hasConcept C141231307 @default.
• W2043886644 hasConcept C166393388 @default.
• W2043886644 hasConcept C18903297 @default.
• W2043886644 hasConcept C195500695 @default.
• W2043886644 hasConcept C2776817793 @default.
• W2043886644 hasConcept C2778914748 @default.
• W2043886644 hasConcept C2778976237 @default.
• W2043886644 hasConcept C34957205 @default.
• W2043886644 hasConcept C54355233 @default.
• W2043886644 hasConcept C67705224 @default.
• W2043886644 hasConcept C69766542 @default.
• W2043886644 hasConcept C78458016 @default.
• W2043886644 hasConcept C86803240 @default.
• W2043886644 hasConcept C90132467 @default.
• W2043886644 hasConceptScore W2043886644C104317684 @default.
• W2043886644 hasConceptScore W2043886644C10879258 @default.
• W2043886644 hasConceptScore W2043886644C141231307 @default.
• W2043886644 hasConceptScore W2043886644C166393388 @default.
• W2043886644 hasConceptScore W2043886644C18903297 @default.
• W2043886644 hasConceptScore W2043886644C195500695 @default.
• W2043886644 hasConceptScore W2043886644C2776817793 @default.
• W2043886644 hasConceptScore W2043886644C2778914748 @default.
• W2043886644 hasConceptScore W2043886644C2778976237 @default.
• W2043886644 hasConceptScore W2043886644C34957205 @default.
• W2043886644 hasConceptScore W2043886644C54355233 @default.
• W2043886644 hasConceptScore W2043886644C67705224 @default.
• W2043886644 hasConceptScore W2043886644C69766542 @default.
• W2043886644 hasConceptScore W2043886644C78458016 @default.
• W2043886644 hasConceptScore W2043886644C86803240 @default.

• next