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- W2043900119 abstract "The recently discovered specific binding sites for benzodiazepines in the central nervous system have been characterized further. Specific 3H-diazepam binding to synaptosomal preparations from rat cerebral cortex is saturable with the dissociation constant for diazepam KD = 3.6 ± 0.1 nM. The maximal amount of specifically bound 3H-diazepam is 0.88 ± 0.05 pmole per mg protein. In the binding assay equilibrium between the specific binding sites and 3H-diazepam is reached within 15 min. Specific 3H-diazepam binding shows a linear dependency on protein up to 3.0 mg protein per assay and a sharp pH-optimum between pH 7.0 to pH 7.4 3H-diazepam binding is temperature dependent with the highest amount bound at 4° C. Specific 3H-diazepam binding is altered by treating the synaptosomal preparations with proteolytic enzymes: trypsin and α-chymotrypsin lead to the complete disappearance of specific 3H-diazepam binding; carboxypeptidase A or B decrease specific 3H-diazepam binding by 36 %, while leucineaminopeptidase was without effect." @default.
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- W2043900119 date "1977-06-01" @default.
- W2043900119 modified "2023-09-25" @default.
- W2043900119 title "Properties of 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex" @default.
- W2043900119 cites W1775749144 @default.
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- W2043900119 doi "https://doi.org/10.1016/0024-3205(77)90191-6" @default.
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