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• W2043901097 abstract "The retina of Arvicanthis niloticus, a diurnal murine rodent closely related to Rattus (rats) and Mus (mice), contains approximately 30% to 35% cones and has several cone-driven functional characteristics found in humans. In this study the organization of these cone photoreceptors was examined, with emphasis on those expressing the S-opsin photopigment (S-cones).Cones were labeled with antibodies against M- and S-opsins. Their topographic arrangement was examined on images of retinal flatmounts using density measures, nearest-neighbor distance, and Voronoi domain analysis. Partial sequencing of the S-opsin DNA was also performed to determine whether this visual pigment was blue/violet or UV sensitive.Cone photoreceptors (estimated total population approximately 1.450 million) came in two distinct types that express either M/L- or S-opsin. Both types were present across the retinal surface. S-cones (approximately 7-8% of the total cone population) achieved a higher density in a discrete temporodorsal sector of the retina. The S-cone mosaic was irregular. Finally, S-cones were likely to be UV sensitive, according to genetic analysis.The topographic arrangement of cone photoreceptors in the retina of the diurnal Nile grass rat A. niloticus represents a highly pertinent model to improve understanding of the pathologic course of and related therapy for retinal disease involving cones." @default.
• W2043901097 created "2016-06-24" @default.
• W2043901097 creator A5001870529 @default.
• W2043901097 creator A5020639669 @default.
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• W2043901097 date "2009-11-01" @default.
• W2043901097 modified "2023-09-30" @default.
• W2043901097 title "Topographic Arrangement of S-cone Photoreceptors in the Retina of the Diurnal Nile Grass Rat (<i>Arvicanthis niloticus</i>)" @default.
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• W2043901097 doi "https://doi.org/10.1167/iovs.09-3896" @default.
• W2043901097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553614" @default.
• W2043901097 hasPublicationYear "2009" @default.
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