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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043901802> ?p ?o ?g. }

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• W2043901802 abstract "Interferons (IFN) α/β and γ induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). We report a natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease. This mutation causes a loss of GAF and ISGF3 activation but is dominant for one cellular phenotype and recessive for the other. It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF." @default.
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• W2043901802 date "2001-07-13" @default.
• W2043901802 modified "2023-10-11" @default.
• W2043901802 title "Impairment of Mycobacterial But Not Viral Immunity by a Germline Human <i>STAT1</i> Mutation" @default.
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• W2043901802 doi "https://doi.org/10.1126/science.1061154" @default.
• W2043901802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11452125" @default.
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