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• W2043901868 abstract "Experimental and theoretical data imply that enzyme motion plays an important role in enzymatic reactions. Enzyme motion can influence both the activation free energy barrier and the degree of barrier recrossing. A hybrid theoretical approach has been developed for the investigation of the relation between enzyme motion and activity. This approach includes both electronic and nuclear quantum effects. It distinguishes between thermally averaged promoting motions that influence the activation free energy barrier and dynamical motions that influence the barrier recrossings. Applications to hydride transfer in liver alcohol dehydrogenase and dihydrofolate reductase resulted in the identification and characterization of important enzyme motions. These applications have also led to the proposal of a network of coupled promoting motions in enzymatic reactions. These concepts have important implications for protein engineering and drug design." @default.
• W2043901868 created "2016-06-24" @default.
• W2043901868 creator A5041302371 @default.
• W2043901868 date "2002-10-11" @default.
• W2043901868 modified "2023-10-15" @default.
• W2043901868 title "Impact of Enzyme Motion on Activity" @default.
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• W2043901868 doi "https://doi.org/10.1021/bi0267137" @default.
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