Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043902807> ?p ?o ?g. }
- W2043902807 endingPage "584" @default.
- W2043902807 startingPage "577" @default.
- W2043902807 abstract "Abstract Remote control of cells : A polypeptide has been made that stimulates proliferation and migration of cells upon photochemical activation. This light‐activated polypeptide enables spatially defined control of cell populations at the scale of tissue organization; this is accomplished without physically contacting the cells or modifying their substrate. magnified image Polypeptide growth and differentiation factors modulate a wide variety of cell behaviors and can be used to manipulate cells in vitro for tissue engineering and basic studies of cell biology. To emulate in vitro the spatial aspect of growth factor function, new methods are needed to generate defined spatial gradients of activity. Polypeptide factors that are engineered to be activated with light provide a method for creating concentration gradients with the fine precision in space and time with which light can be directed. As a first test of this approach, we have chemically synthesized a polypeptide with the sequence of epidermal growth factor in which a critical glutamate is “caged” with a photoremovable group. Photolysis of this polypeptide afforded maximal mitogenic and chemokinetic activity at concentrations at which the caged factor was inactive. Spatially resolved photolysis of the factor resulted in spatial patterning of fibroblasts. This system will be useful for ex vivo tissue engineering and for investigating the interactions of cells with their matrix and the role of chemical gradients in biological pattern formation." @default.
- W2043902807 created "2016-06-24" @default.
- W2043902807 creator A5032617496 @default.
- W2043902807 creator A5057018506 @default.
- W2043902807 creator A5059125436 @default.
- W2043902807 creator A5071879260 @default.
- W2043902807 date "2009-02-06" @default.
- W2043902807 modified "2023-09-30" @default.
- W2043902807 title "Manipulating Cell Migration and Proliferation with a Light-Activated Polypeptide" @default.
- W2043902807 cites W1485721124 @default.
- W2043902807 cites W1573312188 @default.
- W2043902807 cites W1589959819 @default.
- W2043902807 cites W1604583989 @default.
- W2043902807 cites W1894641937 @default.
- W2043902807 cites W1967265143 @default.
- W2043902807 cites W1970794616 @default.
- W2043902807 cites W1978922710 @default.
- W2043902807 cites W1979169277 @default.
- W2043902807 cites W1982062480 @default.
- W2043902807 cites W1992401642 @default.
- W2043902807 cites W1997691487 @default.
- W2043902807 cites W2001401213 @default.
- W2043902807 cites W2002929566 @default.
- W2043902807 cites W2007311583 @default.
- W2043902807 cites W2013768084 @default.
- W2043902807 cites W2016643526 @default.
- W2043902807 cites W2017116537 @default.
- W2043902807 cites W2020799905 @default.
- W2043902807 cites W2022967133 @default.
- W2043902807 cites W2023657035 @default.
- W2043902807 cites W2037810763 @default.
- W2043902807 cites W2047266588 @default.
- W2043902807 cites W2047980414 @default.
- W2043902807 cites W2049766526 @default.
- W2043902807 cites W2050742799 @default.
- W2043902807 cites W2052646014 @default.
- W2043902807 cites W2058620780 @default.
- W2043902807 cites W2059597336 @default.
- W2043902807 cites W2062328606 @default.
- W2043902807 cites W2067843657 @default.
- W2043902807 cites W2071237033 @default.
- W2043902807 cites W2071451059 @default.
- W2043902807 cites W2075713267 @default.
- W2043902807 cites W2076845200 @default.
- W2043902807 cites W2078065578 @default.
- W2043902807 cites W2078338712 @default.
- W2043902807 cites W2080113094 @default.
- W2043902807 cites W2081976353 @default.
- W2043902807 cites W2087833741 @default.
- W2043902807 cites W2089369342 @default.
- W2043902807 cites W2092435369 @default.
- W2043902807 cites W2094891277 @default.
- W2043902807 cites W2098799479 @default.
- W2043902807 cites W2098896496 @default.
- W2043902807 cites W2099322968 @default.
- W2043902807 cites W2112728836 @default.
- W2043902807 cites W2117228071 @default.
- W2043902807 cites W2120604647 @default.
- W2043902807 cites W2141279909 @default.
- W2043902807 cites W2161037388 @default.
- W2043902807 cites W2162411580 @default.
- W2043902807 cites W2164238555 @default.
- W2043902807 cites W2169873791 @default.
- W2043902807 cites W2336590761 @default.
- W2043902807 cites W4247702767 @default.
- W2043902807 cites W4252543254 @default.
- W2043902807 doi "https://doi.org/10.1002/cbic.200800679" @default.
- W2043902807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19165838" @default.
- W2043902807 hasPublicationYear "2009" @default.
- W2043902807 type Work @default.
- W2043902807 sameAs 2043902807 @default.
- W2043902807 citedByCount "12" @default.
- W2043902807 countsByYear W20439028072013 @default.
- W2043902807 countsByYear W20439028072015 @default.
- W2043902807 countsByYear W20439028072016 @default.
- W2043902807 countsByYear W20439028072017 @default.
- W2043902807 countsByYear W20439028072018 @default.
- W2043902807 countsByYear W20439028072019 @default.
- W2043902807 countsByYear W20439028072021 @default.
- W2043902807 crossrefType "journal-article" @default.
- W2043902807 hasAuthorship W2043902807A5032617496 @default.
- W2043902807 hasAuthorship W2043902807A5057018506 @default.
- W2043902807 hasAuthorship W2043902807A5059125436 @default.
- W2043902807 hasAuthorship W2043902807A5071879260 @default.
- W2043902807 hasConcept C118131993 @default.
- W2043902807 hasConcept C12554922 @default.
- W2043902807 hasConcept C1491633281 @default.
- W2043902807 hasConcept C170493617 @default.
- W2043902807 hasConcept C185592680 @default.
- W2043902807 hasConcept C18903297 @default.
- W2043902807 hasConcept C202751555 @default.
- W2043902807 hasConcept C207001950 @default.
- W2043902807 hasConcept C2775960820 @default.
- W2043902807 hasConcept C2776362946 @default.
- W2043902807 hasConcept C2777289219 @default.
- W2043902807 hasConcept C49892992 @default.
- W2043902807 hasConcept C54355233 @default.
- W2043902807 hasConcept C55493867 @default.