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- W2043903178 abstract "The receptor protein tyrosine phosphatase (RPTP) PTPμ mediates distinct cellular responses in nasal and temporal retinal ganglion cell (RGC) axons. PTPμ is permissive for nasal RGC neurite outgrowth and inhibitory to temporal RGCs. In addition, PTPμ causes preferential temporal growth cone collapse. Previous studies demonstrated that PTPμ associates with the scaffolding protein RACK1 and the protein kinase C-δ (PKCδ) isoform in chick retina and that PKCδ activity is required for PTPμ-mediated RGC outgrowth. Using in vitro stripe and collapse assays, we find that PKCδ activity is required for both inhibitory and permissive responses of RGCs to PTPμ, with higher levels of PKCδ activation associated with temporal growth cone collapse and repulsion. A potential mechanism for differential PKCδ activation is due to the gradient of PTPμ expression in the retina. PTPμ is expressed in a high temporal, low nasal step gradient in the retina. In support of this, overexpression of exogenous PTPμ in nasal neurites results in a phenotypic switch from permissive to repulsive in response to PTPμ. Together, these results suggest that the differential expression of PTPμ within the retina is instructive for RGC guidance and that the magnitude of PKCδ activation in response to PTPμ signaling results in the distinct cellular behaviors of nasal and temporal RGCs." @default.
- W2043903178 created "2016-06-24" @default.
- W2043903178 creator A5014403716 @default.
- W2043903178 creator A5065482075 @default.
- W2043903178 date "2004-04-01" @default.
- W2043903178 modified "2023-10-17" @default.
- W2043903178 title "PTPμ signaling via PKCδ is instructive for retinal ganglion cell guidance" @default.
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- W2043903178 doi "https://doi.org/10.1016/j.mcn.2003.12.003" @default.
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- W2043903178 hasPublicationYear "2004" @default.
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