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- W2043904728 abstract "Among potential targets for nonspecific anti-inflammatory immunointervention, three proinflammatory interleukins (ILs) have recently been found to play a pivotal role in rheumatoid arthritis (RA). IL-15 has both chemoattractant and proinflammatory properties and may promote bone destruction. IL-17, a product of T lymphocytes, has proinflammatory effects and induces production of metalloproteinases such as MMP-1. IL-18 not only has proinflammatory, angiogenic, and chemoattractant effects but also promotes cartilage destruction. These cytokines are potential targets for specific or nonspecific anti-inflammatory therapy. Thus, blocking IL-15 by its receptor reduces the severity of experimental collagen-induced arthritis (CIA). In this model, IL-17 levels fall after administration of anti-inflammatory cytokines such as IL-4 or IL-13. Finally, monoclonal anti-IL-18 antibodies prevent streptococcal cell wall arthritis, and IL-18 binding protein, which is a naturally occurring IL-18 inhibitor, prevents CIA." @default.
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- W2043904728 date "2001-12-01" @default.
- W2043904728 modified "2023-09-29" @default.
- W2043904728 title "Novel pro-inflammatory interleukins: potential therapeutic targets in rheumatoid arthritis" @default.
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- W2043904728 doi "https://doi.org/10.1016/s1297-319x(01)00310-4" @default.
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