FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043906117> ?p ?o ?g. }

• W2043906117 endingPage "259" @default.
• W2043906117 startingPage "254" @default.
• W2043906117 abstract "This paper reports the effective treatment of Schistosoma japonicum in a mouse model with long-acting praziquantel (PZQ)-loaded poly(ε-caprolactone) implants. The implants yielded stable, high plasma PZQ concentrations ranging 100-1600 ng/mL during the 40-day investigation period. For assessment of efficacy, the implants were implanted into mice immediately after infection and at 1, 2, 3 and 4 weeks after infection to treat the schistosomes at different developmental stages. All the mice were sacrificed at 6 weeks after infection for worm and egg recovery, worm morphology examination, and histopathological analysis of implantation site tissues. The worm burdens, egg burdens, and numbers of miracidia hatched from the retrieved eggs for all the implant-treated groups (except groups T2-A, T4 and T5) were reduced by 100% when compared with the control group. From groups T2-A, T4 and T5, some schistosome debris was recovered. Eggs were found in only group T5 for which the time between infection and implantation was 4 weeks, which enabled the maturation of juvenile female schistosomes into adult ones that lay eggs. Histopathological observations of implantation tissue showed no evidence of granulomatous foreign-body or lymphoid cell aggregation, demonstrating good biocompatibility of the PZQ implants. These results demonstrate that the long-acting PZQ implants can kill schistosomes at any developmental stages and attenuate/avoid the associated liver damage." @default.
• W2043906117 created "2016-06-24" @default.
• W2043906117 creator A5008233179 @default.
• W2043906117 creator A5011143487 @default.
• W2043906117 creator A5039360390 @default.
• W2043906117 creator A5048677489 @default.
• W2043906117 creator A5056753816 @default.
• W2043906117 creator A5061178696 @default.
• W2043906117 creator A5061812566 @default.
• W2043906117 creator A5064686579 @default.
• W2043906117 creator A5071798264 @default.
• W2043906117 date "2011-11-01" @default.
• W2043906117 modified "2023-10-14" @default.
• W2043906117 title "Schistosoma japonicum: Treatment of different developmental stages in mice with long-acting praziquantel implants" @default.
• W2043906117 cites W1978799378 @default.
• W2043906117 cites W1982756542 @default.
• W2043906117 cites W1986554947 @default.
• W2043906117 cites W1991592821 @default.
• W2043906117 cites W1993430012 @default.
• W2043906117 cites W1996912087 @default.
• W2043906117 cites W2000596925 @default.
• W2043906117 cites W2010707696 @default.
• W2043906117 cites W2022952570 @default.
• W2043906117 cites W2030067934 @default.
• W2043906117 cites W2053360918 @default.
• W2043906117 cites W2062921719 @default.
• W2043906117 cites W2072052728 @default.
• W2043906117 cites W2098680023 @default.
• W2043906117 cites W2125176835 @default.
• W2043906117 cites W2165931008 @default.
• W2043906117 cites W2325224912 @default.
• W2043906117 cites W986478750 @default.
• W2043906117 doi "https://doi.org/10.1016/j.exppara.2011.08.003" @default.
• W2043906117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21856298" @default.
• W2043906117 hasPublicationYear "2011" @default.
• W2043906117 type Work @default.
• W2043906117 sameAs 2043906117 @default.
• W2043906117 citedByCount "3" @default.
• W2043906117 countsByYear W20439061172012 @default.
• W2043906117 countsByYear W20439061172017 @default.
• W2043906117 countsByYear W20439061172022 @default.
• W2043906117 crossrefType "journal-article" @default.
• W2043906117 hasAuthorship W2043906117A5008233179 @default.
• W2043906117 hasAuthorship W2043906117A5011143487 @default.
• W2043906117 hasAuthorship W2043906117A5039360390 @default.
• W2043906117 hasAuthorship W2043906117A5048677489 @default.
• W2043906117 hasAuthorship W2043906117A5056753816 @default.
• W2043906117 hasAuthorship W2043906117A5061178696 @default.
• W2043906117 hasAuthorship W2043906117A5061812566 @default.
• W2043906117 hasAuthorship W2043906117A5064686579 @default.
• W2043906117 hasAuthorship W2043906117A5071798264 @default.
• W2043906117 hasConcept C115961737 @default.
• W2043906117 hasConcept C141071460 @default.
• W2043906117 hasConcept C142724271 @default.
• W2043906117 hasConcept C165901193 @default.
• W2043906117 hasConcept C16685009 @default.
• W2043906117 hasConcept C203014093 @default.
• W2043906117 hasConcept C2776225656 @default.
• W2043906117 hasConcept C2776863245 @default.
• W2043906117 hasConcept C2777123769 @default.
• W2043906117 hasConcept C2778491710 @default.
• W2043906117 hasConcept C2779744950 @default.
• W2043906117 hasConcept C2781411149 @default.
• W2043906117 hasConcept C42407357 @default.
• W2043906117 hasConcept C54355233 @default.
• W2043906117 hasConcept C544855455 @default.
• W2043906117 hasConcept C71924100 @default.
• W2043906117 hasConcept C86803240 @default.
• W2043906117 hasConceptScore W2043906117C115961737 @default.
• W2043906117 hasConceptScore W2043906117C141071460 @default.
• W2043906117 hasConceptScore W2043906117C142724271 @default.
• W2043906117 hasConceptScore W2043906117C165901193 @default.
• W2043906117 hasConceptScore W2043906117C16685009 @default.
• W2043906117 hasConceptScore W2043906117C203014093 @default.
• W2043906117 hasConceptScore W2043906117C2776225656 @default.
• W2043906117 hasConceptScore W2043906117C2776863245 @default.
• W2043906117 hasConceptScore W2043906117C2777123769 @default.
• W2043906117 hasConceptScore W2043906117C2778491710 @default.
• W2043906117 hasConceptScore W2043906117C2779744950 @default.
• W2043906117 hasConceptScore W2043906117C2781411149 @default.
• W2043906117 hasConceptScore W2043906117C42407357 @default.
• W2043906117 hasConceptScore W2043906117C54355233 @default.
• W2043906117 hasConceptScore W2043906117C544855455 @default.
• W2043906117 hasConceptScore W2043906117C71924100 @default.
• W2043906117 hasConceptScore W2043906117C86803240 @default.
• W2043906117 hasFunder F4320327563 @default.
• W2043906117 hasIssue "3" @default.
• W2043906117 hasLocation W20439061171 @default.
• W2043906117 hasLocation W20439061172 @default.
• W2043906117 hasOpenAccess W2043906117 @default.
• W2043906117 hasPrimaryLocation W20439061171 @default.
• W2043906117 hasRelatedWork W1968226741 @default.
• W2043906117 hasRelatedWork W2065600419 @default.
• W2043906117 hasRelatedWork W2156322133 @default.
• W2043906117 hasRelatedWork W2611831451 @default.
• W2043906117 hasRelatedWork W2965085321 @default.
• W2043906117 hasRelatedWork W3117749821 @default.
• W2043906117 hasRelatedWork W4220753533 @default.

• next