FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043907950> ?p ?o ?g. }

• W2043907950 endingPage "170" @default.
• W2043907950 startingPage "159" @default.
• W2043907950 abstract "The present study examined the stress responsiveness of the hypothalamic-pituitary-adrenal axis in relation to the properties of corticosteroid receptors in the brain and pituitary of old (30 months) and young (3 months) male Brown Norway rats. Adrenocorticotropin hormone (ACTH) and corticosterone (B) were measured following exposure to novelty and to a conditioned emotional stimulus in blood samples sequentially obtained from chronically cannulated animals. Mineralocorticoid (MR) and glucocorticoid (GR) receptors were quantified by radioligand binding assay and in situ hybridization. The receptor binding constants were determined in tissue of rats that were adrenalectomized 24 hours previously, whereas gene expression was measured in the brain of intact animals. Aged Brown Norway rats showed a small but significant elevation in basal circulating ACTH level. The conditioned emotional stimulus, rather than the exposure to novelty, triggered a more than two-times higher ACTH response in the aged compared to the young rat. The termination of the stress-induced ACTH response seemed to proceed more efficiently in the aged rat. Basal and stress-induced total plasma B level did not differ in the young and old rats. The latter showed a 65% lower binding capacity of corticosteroid-binding globulin (CBG). Interestingly, in the aged rat the stress-induced rise in free circulating plasma B level was not elevated, but only prolonged. The hippocampus of aged rats displayed a decrease of maximally 44% in the apparent Bmax of MR, but no change in GR number. The Bmax of GR showed a 40% reduction in the hypothalamus and a 50% reduction in the anterior pituitary. GR affinity was considerably increased in the anterior pituitary, but was unchanged in the hippocampus and hypothalamus. Old age affected MR and GR gene expression differentially. GR mRNA was significantly reduced in cell field CA3 (−42%), CA4 (−41%) and the dentate gyrus (−26%) of the dorsal hippocampus, but did not change either in hippocampal cell field CA1 or in the hypothalamic paraventricular nucleus (PVN) of the old rat. There was no significant difference in MR mRNA between young and aged rats in the different cell fields of the hippocampus. The aged rat, therefore, is characterized by site- and receptor-specific changes in binding constants as well as by changes in receptor transcription and translation. The data demonstrate that in the old Brown Norway rats, a conditioned emotional stimulus results in enhanced pituitary ACTH release. Since the adrenocortical secretion of B was not different between the young and old animals, this observation suggests a reduced sensitivity of the adrenal to circulating ACTH in the aged rats. The data do not support the glucocorticoid cascade hypothesis; the Brown Norway rat is characterized by an increased ACTH response to a conditioned stress stimulus while the negative feedback action of glucocorticoids is not impaired. The present data support the concept of an age-induced change in the balance of central MR- and GR-mediated effects which consequently affects the set-point of homeostatic control and in turn, may progressively lead to a condition of age-related neuroendocrine and cognitive disturbances." @default.
• W2043907950 created "2016-06-24" @default.
• W2043907950 creator A5022502911 @default.
• W2043907950 creator A5030678985 @default.
• W2043907950 creator A5058974194 @default.
• W2043907950 creator A5060790200 @default.
• W2043907950 date "1992-01-01" @default.
• W2043907950 modified "2023-10-15" @default.
• W2043907950 title "The effect of aging on stress responsiveness and central corticosteroid receptors in the Brown Norway rat" @default.
• W2043907950 cites W1489028475 @default.
• W2043907950 cites W1536700299 @default.
• W2043907950 cites W1591042414 @default.
• W2043907950 cites W1642124290 @default.
• W2043907950 cites W1775749144 @default.
• W2043907950 cites W1977143695 @default.
• W2043907950 cites W1979528596 @default.
• W2043907950 cites W1982692135 @default.
• W2043907950 cites W1985114728 @default.
• W2043907950 cites W1995549578 @default.
• W2043907950 cites W1997805881 @default.
• W2043907950 cites W2002264389 @default.
• W2043907950 cites W2003050811 @default.
• W2043907950 cites W2008050722 @default.
• W2043907950 cites W2008213128 @default.
• W2043907950 cites W2010669553 @default.
• W2043907950 cites W2014212152 @default.
• W2043907950 cites W2015497140 @default.
• W2043907950 cites W2015613847 @default.
• W2043907950 cites W2018203792 @default.
• W2043907950 cites W2022658269 @default.
• W2043907950 cites W2022709193 @default.
• W2043907950 cites W2024255841 @default.
• W2043907950 cites W2026488506 @default.
• W2043907950 cites W2028067058 @default.
• W2043907950 cites W2029417981 @default.
• W2043907950 cites W2031667205 @default.
• W2043907950 cites W2032651138 @default.
• W2043907950 cites W2033948248 @default.
• W2043907950 cites W2034122751 @default.
• W2043907950 cites W2040761658 @default.
• W2043907950 cites W2042267004 @default.
• W2043907950 cites W2044270340 @default.
• W2043907950 cites W2045534445 @default.
• W2043907950 cites W2046155805 @default.
• W2043907950 cites W2047317140 @default.
• W2043907950 cites W2052783136 @default.
• W2043907950 cites W2055426885 @default.
• W2043907950 cites W2056138533 @default.
• W2043907950 cites W2072847456 @default.
• W2043907950 cites W2072969119 @default.
• W2043907950 cites W2074802748 @default.
• W2043907950 cites W2077163191 @default.
• W2043907950 cites W2077993951 @default.
• W2043907950 cites W2086095885 @default.
• W2043907950 cites W2088766302 @default.
• W2043907950 cites W2090024435 @default.
• W2043907950 cites W2090215646 @default.
• W2043907950 cites W2093500055 @default.
• W2043907950 cites W2097013135 @default.
• W2043907950 cites W2109887747 @default.
• W2043907950 cites W2113962949 @default.
• W2043907950 cites W2134033459 @default.
• W2043907950 cites W2145827936 @default.
• W2043907950 cites W2162972693 @default.
• W2043907950 cites W2321781784 @default.
• W2043907950 cites W2321915185 @default.
• W2043907950 cites W2321972530 @default.
• W2043907950 cites W2335168271 @default.
• W2043907950 cites W4237012674 @default.
• W2043907950 doi "https://doi.org/10.1016/0197-4580(92)90024-r" @default.
• W2043907950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1311803" @default.
• W2043907950 hasPublicationYear "1992" @default.
• W2043907950 type Work @default.
• W2043907950 sameAs 2043907950 @default.
• W2043907950 citedByCount "113" @default.
• W2043907950 countsByYear W20439079502012 @default.
• W2043907950 countsByYear W20439079502013 @default.
• W2043907950 countsByYear W20439079502014 @default.
• W2043907950 countsByYear W20439079502015 @default.
• W2043907950 countsByYear W20439079502017 @default.
• W2043907950 countsByYear W20439079502019 @default.
• W2043907950 countsByYear W20439079502022 @default.
• W2043907950 crossrefType "journal-article" @default.
• W2043907950 hasAuthorship W2043907950A5022502911 @default.
• W2043907950 hasAuthorship W2043907950A5030678985 @default.
• W2043907950 hasAuthorship W2043907950A5058974194 @default.
• W2043907950 hasAuthorship W2043907950A5060790200 @default.
• W2043907950 hasConcept C126322002 @default.
• W2043907950 hasConcept C134018914 @default.
• W2043907950 hasConcept C170493617 @default.
• W2043907950 hasConcept C185592680 @default.
• W2043907950 hasConcept C189135053 @default.
• W2043907950 hasConcept C2776069600 @default.
• W2043907950 hasConcept C2776804153 @default.
• W2043907950 hasConcept C2777003273 @default.
• W2043907950 hasConcept C2778024521 @default.
• W2043907950 hasConcept C2779306644 @default.
• W2043907950 hasConcept C2780352252 @default.

• next