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• W2043908137 endingPage "20" @default.
• W2043908137 startingPage "10" @default.
• W2043908137 abstract "The identification of 2'-O-methyl substituted adenosine-3',5'-cyclic monophosphate (cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs, also known as Epac1 and Epac2), has ushered in a new era of cyclic nucleotide research in which previously unrecognized signalling properties of the second messenger cAMP have been revealed. These Epac-Selective Cyclic AMP Analogs (ESCAs) incorporate a 2'-O-methyl substitution on the ribose ring of cAMP, a modification that impairs their ability to activate protein kinase A (PKA), while leaving intact their ability to activate Epac (the Exchange Protein directly Activated by Cyclic AMP). One such ESCA in wide-spread use is 8-pCPT-2'-O-Me-cAMP. It is a cell-permeant derivative of 2'-O-Me-cAMP, and it is a super activator of Epac. A wealth of newly published studies demonstrate that 8-pCPT-2'-O-Me-cAMP is a unique tool with which to asses atypical actions of cAMP that are PKA-independent. Particularly intriguing are recent reports demonstrating that ESCAs reproduce the PKA-independent actions of ligands known to stimulate Class I (Family A) and Class II (Family B) GTP-binding protein-coupled receptors (GPCRs). This topical review summarizes the current state of knowledge regarding the molecular pharmacology and signal transduction properties of Epac-selective cAMP analogs. Special attention is focused on the rational drug design of ESCAs in order to improve their Epac selectivity, membrane permeability, and stability. Also emphasized is the usefulness of ESCAs as new tools with which to assess the role of Epac as a determinant of intracellular Ca2+ signalling, ion channel function, neurotransmitter release, and hormone secretion." @default.
• W2043908137 created "2016-06-24" @default.
• W2043908137 creator A5020235785 @default.
• W2043908137 creator A5049654018 @default.
• W2043908137 creator A5058178334 @default.
• W2043908137 date "2008-01-01" @default.
• W2043908137 modified "2023-09-29" @default.
• W2043908137 title "Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors" @default.
• W2043908137 cites W1492821183 @default.
• W2043908137 cites W1547589333 @default.
• W2043908137 cites W1571595997 @default.
• W2043908137 cites W1594572310 @default.
• W2043908137 cites W1595835172 @default.
• W2043908137 cites W1654777050 @default.
• W2043908137 cites W1885709862 @default.
• W2043908137 cites W1939317253 @default.
• W2043908137 cites W1965112593 @default.
• W2043908137 cites W1965253511 @default.
• W2043908137 cites W1965963242 @default.
• W2043908137 cites W1967969238 @default.
• W2043908137 cites W1970723166 @default.
• W2043908137 cites W1971685742 @default.
• W2043908137 cites W1971748110 @default.
• W2043908137 cites W1973983376 @default.
• W2043908137 cites W1977929393 @default.
• W2043908137 cites W1978365857 @default.
• W2043908137 cites W1979560148 @default.
• W2043908137 cites W1981368778 @default.
• W2043908137 cites W1987890424 @default.
• W2043908137 cites W1992718424 @default.
• W2043908137 cites W1994086577 @default.
• W2043908137 cites W2007255861 @default.
• W2043908137 cites W2009096988 @default.
• W2043908137 cites W2013910844 @default.
• W2043908137 cites W2015746168 @default.
• W2043908137 cites W2016095963 @default.
• W2043908137 cites W2017685664 @default.
• W2043908137 cites W2018058179 @default.
• W2043908137 cites W2018372068 @default.
• W2043908137 cites W2020607474 @default.
• W2043908137 cites W2039629780 @default.
• W2043908137 cites W2039870127 @default.
• W2043908137 cites W2040278047 @default.
• W2043908137 cites W2041028158 @default.
• W2043908137 cites W2050672068 @default.
• W2043908137 cites W2053079477 @default.
• W2043908137 cites W2054454154 @default.
• W2043908137 cites W2055622424 @default.
• W2043908137 cites W2061905525 @default.
• W2043908137 cites W2062032373 @default.
• W2043908137 cites W2062097815 @default.
• W2043908137 cites W2063716341 @default.
• W2043908137 cites W2064579697 @default.
• W2043908137 cites W2065612361 @default.
• W2043908137 cites W2066859825 @default.
• W2043908137 cites W2067962261 @default.
• W2043908137 cites W2068064315 @default.
• W2043908137 cites W2074158980 @default.
• W2043908137 cites W2075846921 @default.
• W2043908137 cites W2076128131 @default.
• W2043908137 cites W2078037416 @default.
• W2043908137 cites W2080875376 @default.
• W2043908137 cites W2082614106 @default.
• W2043908137 cites W2083049815 @default.
• W2043908137 cites W2095182410 @default.
• W2043908137 cites W2097135764 @default.
• W2043908137 cites W2099084891 @default.
• W2043908137 cites W2102425770 @default.
• W2043908137 cites W2105100736 @default.
• W2043908137 cites W2106435662 @default.
• W2043908137 cites W2106709311 @default.
• W2043908137 cites W2107034951 @default.
• W2043908137 cites W2110160705 @default.
• W2043908137 cites W2111694965 @default.
• W2043908137 cites W2112281734 @default.
• W2043908137 cites W2112534180 @default.
• W2043908137 cites W2113303890 @default.
• W2043908137 cites W2116127675 @default.
• W2043908137 cites W2118377141 @default.
• W2043908137 cites W2120904086 @default.
• W2043908137 cites W2125550441 @default.
• W2043908137 cites W2126704964 @default.
• W2043908137 cites W2131970968 @default.
• W2043908137 cites W2132023176 @default.
• W2043908137 cites W2133096761 @default.
• W2043908137 cites W2133553247 @default.
• W2043908137 cites W2136621696 @default.
• W2043908137 cites W2141412000 @default.
• W2043908137 cites W2143563119 @default.
• W2043908137 cites W2145824107 @default.
• W2043908137 cites W2147297045 @default.
• W2043908137 cites W2153618088 @default.
• W2043908137 cites W2154558722 @default.
• W2043908137 cites W2155823638 @default.
• W2043908137 cites W2158387009 @default.
• W2043908137 cites W2158726350 @default.
• W2043908137 cites W2158962985 @default.
• W2043908137 cites W2161057669 @default.

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