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- W2043908270 abstract "Letters1 May 1994Effects of Lovastatin and Pravastatin on Coronary Artery DiseaseMark R. Goldstein, MDMark R. Goldstein, MDCrozer-Chester Medical Center; Upland, PA 19013Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-9-199405010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In comparing the Monitored Atherosclerosis Regression Study (MARS) [1] with another recently published coronary prevention trial that also tested reductase inhibitors against placebo, it appears that a decreased coronary event rate may be related to the particular reductase inhibitor.The MARS trial was a randomized, double-blind, placebo-controlled, multicenter angiographic trial testing the effects of lovastatin on the progression of coronary artery disease in patients with angiographically proven coronary disease. Most patients had multiple risk factors for the disease. Treatment with diet and lovastatin (80 mg/d) for 2.2 years had a favorable effect on lipoprotein levels and angiographically ...References1. Blankenhorn DH, Azen SP, Kramsch DM, Mack WJ, Cashin-Hemphill L, Hodis HN, et al. Coronary angiographic changes with lovastatin therapy. The Monitored Atherosclerosis Regression Study (MARS). Ann Intern Med. 1993; 119:969-76. Google Scholar2. Effects of pravastatin in patients with serum total cholesterol levels from 5.2 to 7.8 mmol/liter (200 to 300 mg/dL) plus two additional atherosclerotic risk factors. The Pravastatin Multinational Study Group for Cardiac Risk Patients. Am J Cardiol. 1993; 72:1031-7. Google Scholar3. Jungnickel PW, Cantral KA, Maloley PA. Pravastatin: a new drug for the treatment of hypercholesterolemia. Clin Pharm. 1992; 11:677-89. Google Scholar Author, Article, and Disclosure InformationAffiliations: Crozer-Chester Medical Center; Upland, PA 19013 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-term Clinical Outcomes of Statin Use for Chronic Heart Failure: A Meta-analysis of 15 Prospective StudiesLovastatin and sudden unexpected death in epilepsy: A matter for debateEffects of Statin Treatment on Cardiac Function in Patients With Chronic Heart Failure: A Meta-Analysis of Randomized Controlled TrialsLovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results 1 May 1994Volume 120, Issue 9Page: 811-812KeywordsCholesterolCoronary arteriesDietLipoproteinsMedical risk factorsMyocardial infarctionPercutaneous transluminal coronary angioplastyStable coronary artery diseaseSurgeryUnstable angina Issue Published: 1 May 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ..." @default.
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- W2043908270 title "Effects of Lovastatin and Pravastatin on Coronary Artery Disease" @default.
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