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- W2043909105 abstract "Glucocorticoids regulate a plethora of physiological processes, and are widely used clinically as anti-inflammatory drugs. Their effects are mediated by the glucocorticoid receptor (GR), a ligand-activated transcription factor. Currently, zebrafish embryos are being developed into a model system for GR research, since they are easy to manipulate genetically and their phenotype can easily be visualized because of their transparent bodies. In addition, the zebrafish GR gene shows a relatively high level of similarity with its human equivalent. First, both the zebrafish and the human genome contain only a single gene encoding the GR. In all other fish species studied thus far, two GR genes have been found. Second, the zebrafish contains a C-terminal GR splice variant with high similarity to the human GRβ, which has been shown to be a dominant-negative inhibitor of the canonical GRα and may be involved in glucocorticoid resistance. Thus, zebrafish embryos are potentially a useful model system for glucocorticoid receptor research, but currently only a limited number of tools is available. In this review, we discuss which tools are available and which need to be developed, in order to exploit the full potential of the zebrafish as a model system for GR research." @default.
- W2043909105 created "2016-06-24" @default.
- W2043909105 creator A5022892166 @default.
- W2043909105 creator A5065083412 @default.
- W2043909105 creator A5079226834 @default.
- W2043909105 date "2009-05-01" @default.
- W2043909105 modified "2023-10-01" @default.
- W2043909105 title "The zebrafish as a model system for glucocorticoid receptor research" @default.
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- W2043909105 doi "https://doi.org/10.1016/j.cbpa.2008.12.014" @default.
- W2043909105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19168143" @default.
- W2043909105 hasPublicationYear "2009" @default.
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