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- W2043909544 abstract "Aim: The aim was to explore the epigenetic mechanisms underlying cervical oncogenesis, we compared the level of microRNA-34a (miR-34a), p53, and cell cycle-related protein CDK4 within normal cervical tissue, cervical intraepithelial neoplasia III (CINIII) tissue, and cervical cancer tissue. Methods: Fresh normal cervical tissue, CINIII tissue, and cervical cancer tissue specimens were collected from patients not receiving chemotherapy, radiotherapy or immunotherapy prior to surgery. Stem-loop real-time polymerase chain reaction was employed to analyze the level of miR-34a. p53 was detected by immunohistochemistry, and cell cycle-related protein CDK4 was detected by Western blot. Results: The positive rates of p53 in CINIII and cervical cancer tissues were 35% and 68%, respectively ( P P P P Conclusion: With the progression of cervical cancer lesions, the positive rate of p53 was greatly increased which may indicate its mutation, while miR-34a was down-regulated and CDK4 was up-regulated, which suggested that all these factors might be involved in the process of cervical oncogenesis." @default.
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- W2043909544 date "2015-01-01" @default.
- W2043909544 modified "2023-09-25" @default.
- W2043909544 title "The Involvement of p53-miR-34a-CDK4 Signaling During the Development of Cervical Cancer" @default.
- W2043909544 doi "https://doi.org/10.4103/2395-3977.155928" @default.
- W2043909544 hasPublicationYear "2015" @default.
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