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• W2043911212 abstract "ObjectiveEven in egg donor cycles, 30-40% of blastocysts are chromosomally abnormal. The objective of this study is to compare the outcomes in first time egg donor recipient cycles of fresh embryo transfers vs cryo transfers with or without PGS.DesignRetrospective cohort study.Materials and Methods120 recipients having their first donor egg transfer were included in this study. Recipients either had a fresh transfer or elective freeze all of available blastocysts. Freeze all patients elected to either have trophectoderm biopsy performed prior to vitrification or not. Trophectoderm biopsy was performed on day 5 or 6 depending on degree of expansion. Biopsied cells were analyzed by array CGH and only euploid embryos were replaced. The endometrial preparation was the same in all three groups of recipients.ResultsTabled 1Donor Egg Blastocyst TransfersFresh TransferFrozen TransferFrozen PGS TransferTransfers (N=)553530Ave # embryos transferred1.81.71.6Clinical Pregnancy Rate67.3% (37/55)57.1% (20/35)83.3% (25/30)SAB Rate10.8% (4/37)15.0% (3/20)8.0% (2/25)Ongoing/Delivered Rate58.2% (32/55)48.6% (17/35)76.7% (23/30)Implantation Rate53.9% (55/102)44.3% (27/61)67.1% (49/73) Open table in a new tab ConclusionThere was no difference in outcomes comparing fresh transfers and frozen transfers. Pregnancy outcomes were significantly higher in the PGS FET group compared to FET only for Pregnancy rates (p<0.05), ongoing pregnancy rates (p<0.05) and Implantation rates (p<0.025). Donor egg recipient transfers are an ideal paradigm to assess the effect of PGS due to favorable prognosis and controlled uterine environment . In this ideal patient population , PGS of donor egg embryos showed high implantation rates and low miscarriage rates suggesting PGS may be considered for recipient patients requesting PGS of donor egg embryos. ObjectiveEven in egg donor cycles, 30-40% of blastocysts are chromosomally abnormal. The objective of this study is to compare the outcomes in first time egg donor recipient cycles of fresh embryo transfers vs cryo transfers with or without PGS. Even in egg donor cycles, 30-40% of blastocysts are chromosomally abnormal. The objective of this study is to compare the outcomes in first time egg donor recipient cycles of fresh embryo transfers vs cryo transfers with or without PGS. DesignRetrospective cohort study. Retrospective cohort study. Materials and Methods120 recipients having their first donor egg transfer were included in this study. Recipients either had a fresh transfer or elective freeze all of available blastocysts. Freeze all patients elected to either have trophectoderm biopsy performed prior to vitrification or not. Trophectoderm biopsy was performed on day 5 or 6 depending on degree of expansion. Biopsied cells were analyzed by array CGH and only euploid embryos were replaced. The endometrial preparation was the same in all three groups of recipients. 120 recipients having their first donor egg transfer were included in this study. Recipients either had a fresh transfer or elective freeze all of available blastocysts. Freeze all patients elected to either have trophectoderm biopsy performed prior to vitrification or not. Trophectoderm biopsy was performed on day 5 or 6 depending on degree of expansion. Biopsied cells were analyzed by array CGH and only euploid embryos were replaced. The endometrial preparation was the same in all three groups of recipients. ResultsTabled 1Donor Egg Blastocyst TransfersFresh TransferFrozen TransferFrozen PGS TransferTransfers (N=)553530Ave # embryos transferred1.81.71.6Clinical Pregnancy Rate67.3% (37/55)57.1% (20/35)83.3% (25/30)SAB Rate10.8% (4/37)15.0% (3/20)8.0% (2/25)Ongoing/Delivered Rate58.2% (32/55)48.6% (17/35)76.7% (23/30)Implantation Rate53.9% (55/102)44.3% (27/61)67.1% (49/73) Open table in a new tab ConclusionThere was no difference in outcomes comparing fresh transfers and frozen transfers. Pregnancy outcomes were significantly higher in the PGS FET group compared to FET only for Pregnancy rates (p<0.05), ongoing pregnancy rates (p<0.05) and Implantation rates (p<0.025). Donor egg recipient transfers are an ideal paradigm to assess the effect of PGS due to favorable prognosis and controlled uterine environment . In this ideal patient population , PGS of donor egg embryos showed high implantation rates and low miscarriage rates suggesting PGS may be considered for recipient patients requesting PGS of donor egg embryos. There was no difference in outcomes comparing fresh transfers and frozen transfers. Pregnancy outcomes were significantly higher in the PGS FET group compared to FET only for Pregnancy rates (p<0.05), ongoing pregnancy rates (p<0.05) and Implantation rates (p<0.025). Donor egg recipient transfers are an ideal paradigm to assess the effect of PGS due to favorable prognosis and controlled uterine environment . In this ideal patient population , PGS of donor egg embryos showed high implantation rates and low miscarriage rates suggesting PGS may be considered for recipient patients requesting PGS of donor egg embryos." @default.
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• W2043911212 date "2014-09-01" @default.
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• W2043911212 title "Selection of chromosomally normal embryos improves egg donor frozen transfer pregnancy rates" @default.
• W2043911212 doi "https://doi.org/10.1016/j.fertnstert.2014.07.286" @default.
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