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- W2043920088 abstract "A baboon animal model has been developed to study the kinetics of platelets doubly labeled with 51-Cr, a cytoplasmic label, and diazotized 125-I-iodosulfanilic acid (D 125-ISA), which binds to glycoprotein components of the platelet membrane. This study was undertaken to evaluate the possible usefulness of this platelet label, and to extend to primates previous observations of D 125-ISA-labeled platelets in rabbits. D 125-ISA-platelet activity disappeared exponentially with a mean t12 of 0.90 days ± 0.11. Labeling 51-Cr-platelets with D 125-ISA resulted in a modest but significant reduction in the baseline 51-Cr-platelet survival time (from 5.5 ± 0.2 days to 4.7 ± 0.4; p < 0.02). 51-Cr and D 125-ISA kinetics were not changed by the administration of aspirin-dipyridamole, sudoxicam, or high molecular weight dextran. These studies suggest that platelet membrane components are continually lost during circulation in vivo, but that this process is unaffected by pharmacologic inhibition of platelet function." @default.
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- W2043920088 date "1981-07-01" @default.
- W2043920088 modified "2023-09-27" @default.
- W2043920088 title "Survival of baboon platelets labeled with diazotized (125-1)-iodosulfanilic acid: No effect of drugs that modify platelet behavior" @default.
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- W2043920088 doi "https://doi.org/10.1016/0049-3848(81)90246-2" @default.
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