Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043921937> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2043921937 endingPage "299" @default.
- W2043921937 startingPage "291" @default.
- W2043921937 abstract "Plasma immunoreactive atrial natriuretic factor (irANF) levels and the effects of alpha-human ANF (alpha-hANF) infusion were investigated in 7 patients with liver cirrhosis and ascites. Under basal conditions, supine blood pressure (BP) averaged 136/76 +/- 9/4 mm Hg (mean +/- SEM). Plasma irANF concentrations (124 +/- 33 pg/ml) were higher (p less than 0.01) than those in age-matched normal subjects (47 +/- 5 pg/ml). Plasma renin activity (PRA 5.9 +/- 2.2 ng/ml/h), aldosterone (18 +/- 7 ng/dl) and norepinephrine (NE, 66 +/- 5 ng/dl) levels were also elevated compared to the age-related normal range. Alpha-hANF infusion for 60 min at 0.036 micrograms/kg/min decreased the mean BP (-14%; p less than 0.05), increased PRA (+179%; p less than 0.05) and plasma NE (+24%; p less than 0.05). Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), diuresis and natriuresis were not modified. A subsequent 60-min infusion of alpha-hANF at 0.067 micrograms/kg/min produced a marked fall in mean BP (-26%; p less than 0.001), hemoconcentration (hematocrit +6%; p less than 0.001) despite stable body fluid balance and a further increase in PRA (+350%, p less than 0.005). GFR and ERPF were severely reduced (-55 and -56%, respectively; p less than 0.001), while diuresis and natriuresis were not modified. Plasma aldosterone was unaltered during, but rose (+72%; p less than 0.01) after the cessation of alpha-hANF infusion. Variations in natriuresis during alpha-hANF infusion correlated positively with BP (r = 0.47; p less than 0.01), ERPF (r = 0.53; p less than 0.01) or GFR (r = 0.51; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2043921937 created "2016-06-24" @default.
- W2043921937 creator A5011540184 @default.
- W2043921937 creator A5022729429 @default.
- W2043921937 creator A5024001556 @default.
- W2043921937 creator A5047591330 @default.
- W2043921937 creator A5063806503 @default.
- W2043921937 creator A5068780398 @default.
- W2043921937 creator A5086496495 @default.
- W2043921937 date "1989-01-01" @default.
- W2043921937 modified "2023-09-25" @default.
- W2043921937 title "Hypotension and Renal Impairment during Infusion of Atrial Natriuretic Factor in Liver Cirrhosis with Ascites" @default.
- W2043921937 doi "https://doi.org/10.1159/000167983" @default.
- W2043921937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2530903" @default.
- W2043921937 hasPublicationYear "1989" @default.
- W2043921937 type Work @default.
- W2043921937 sameAs 2043921937 @default.
- W2043921937 citedByCount "15" @default.
- W2043921937 countsByYear W20439219372022 @default.
- W2043921937 crossrefType "journal-article" @default.
- W2043921937 hasAuthorship W2043921937A5011540184 @default.
- W2043921937 hasAuthorship W2043921937A5022729429 @default.
- W2043921937 hasAuthorship W2043921937A5024001556 @default.
- W2043921937 hasAuthorship W2043921937A5047591330 @default.
- W2043921937 hasAuthorship W2043921937A5063806503 @default.
- W2043921937 hasAuthorship W2043921937A5068780398 @default.
- W2043921937 hasAuthorship W2043921937A5086496495 @default.
- W2043921937 hasConcept C126322002 @default.
- W2043921937 hasConcept C134018914 @default.
- W2043921937 hasConcept C138976137 @default.
- W2043921937 hasConcept C142225936 @default.
- W2043921937 hasConcept C159641895 @default.
- W2043921937 hasConcept C174459258 @default.
- W2043921937 hasConcept C198710026 @default.
- W2043921937 hasConcept C21652263 @default.
- W2043921937 hasConcept C2778525890 @default.
- W2043921937 hasConcept C2779547328 @default.
- W2043921937 hasConcept C2780011235 @default.
- W2043921937 hasConcept C2780959883 @default.
- W2043921937 hasConcept C2781073237 @default.
- W2043921937 hasConcept C2908982287 @default.
- W2043921937 hasConcept C71924100 @default.
- W2043921937 hasConcept C84393581 @default.
- W2043921937 hasConceptScore W2043921937C126322002 @default.
- W2043921937 hasConceptScore W2043921937C134018914 @default.
- W2043921937 hasConceptScore W2043921937C138976137 @default.
- W2043921937 hasConceptScore W2043921937C142225936 @default.
- W2043921937 hasConceptScore W2043921937C159641895 @default.
- W2043921937 hasConceptScore W2043921937C174459258 @default.
- W2043921937 hasConceptScore W2043921937C198710026 @default.
- W2043921937 hasConceptScore W2043921937C21652263 @default.
- W2043921937 hasConceptScore W2043921937C2778525890 @default.
- W2043921937 hasConceptScore W2043921937C2779547328 @default.
- W2043921937 hasConceptScore W2043921937C2780011235 @default.
- W2043921937 hasConceptScore W2043921937C2780959883 @default.
- W2043921937 hasConceptScore W2043921937C2781073237 @default.
- W2043921937 hasConceptScore W2043921937C2908982287 @default.
- W2043921937 hasConceptScore W2043921937C71924100 @default.
- W2043921937 hasConceptScore W2043921937C84393581 @default.
- W2043921937 hasIssue "4" @default.
- W2043921937 hasLocation W20439219371 @default.
- W2043921937 hasLocation W20439219372 @default.
- W2043921937 hasOpenAccess W2043921937 @default.
- W2043921937 hasPrimaryLocation W20439219371 @default.
- W2043921937 hasRelatedWork W1799770855 @default.
- W2043921937 hasRelatedWork W1997758915 @default.
- W2043921937 hasRelatedWork W2002038679 @default.
- W2043921937 hasRelatedWork W2009931840 @default.
- W2043921937 hasRelatedWork W2033709155 @default.
- W2043921937 hasRelatedWork W2043921937 @default.
- W2043921937 hasRelatedWork W2048449846 @default.
- W2043921937 hasRelatedWork W2068631477 @default.
- W2043921937 hasRelatedWork W2155976167 @default.
- W2043921937 hasRelatedWork W66262986 @default.
- W2043921937 hasVolume "9" @default.
- W2043921937 isParatext "false" @default.
- W2043921937 isRetracted "false" @default.
- W2043921937 magId "2043921937" @default.
- W2043921937 workType "article" @default.