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• W2043926043 startingPage "4846" @default.
• W2043926043 abstract "In 1988 John Cairns, Julie Overbaugh, and Stephan Miller published a paper entitled “The origin of mutants,” in which they suggested that bacteria could choose which mutations to make (11). Shortly thereafter, Cairns and I began collaborating on a National Science Foundation-funded project to investigate the genetic basis of what was popularly called “directed mutation” (although at the time we were calling it “selection-dependent mutation,” which now seems as good a name as any). Our plan was to mutagenize an appropriate strain of Escherichia coli and identify and characterize variants defective in selection-dependent mutation. Cairns and coworkers had been investigating a strain called SM195, described in their original paper (11). However, the mechanisms of mutation in this strain had proved to be complicated, and we wanted a new experimental subject. We were setting up to investigate selection-induced activation of the cryptic bgl operon (36), when Jeffrey Miller gave us a Lac− strain, called α45, that he said had a high rate of reversion to Lac+ after plating on minimum lactose medium. The lac allele in this strain is a fusion of lacI to lacZ that eliminates the lac regulatory region as well as several residues of lacI and lacZ; transcription of the fusion is constitutive, initiating at the lacI promoter (7). α45 has a +1 frameshift mutation, lacI33, in the lacI coding region (12). Miller and coworkers have used several similar strains to study various mutational mechanisms (52, 67). As in many of the strains that originated with Jacob and Monod, proAB and lac are deleted from the chromosome and carried on an episome, F′128. This arrangement greatly facilitates genetic manipulations and turned out to be important to adaptive mutation. We mated the episome from α45 into a Δ(lac-pro) recipient that we had made rifampin resistant and named the new strain FC40 (Foster and Cairns #40)." @default.
• W2043926043 created "2016-06-24" @default.
• W2043926043 creator A5020453712 @default.
• W2043926043 date "2004-08-01" @default.
• W2043926043 modified "2023-09-27" @default.
• W2043926043 title "Adaptive Mutation in <i>Escherichia coli</i>" @default.
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• W2043926043 doi "https://doi.org/10.1128/jb.186.15.4846-4852.2004" @default.
• W2043926043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/451643" @default.
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