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• W2043928736 abstract "HomeCirculationVol. 112, No. 3Vena Cava Filters Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBVena Cava FiltersDo We Know All That We Need to Know? Jack Ansell Jack AnsellJack Ansell From the Department of Medicine, Boston University School of Medicine, Boston, Mass. Search for more papers by this author Originally published19 Jul 2005https://doi.org/10.1161/CIRCULATIONAHA.105.547828Circulation. 2005;112:298–299Considerable progress has been made in the last decade in understanding the natural history of “treated” venous thromboembolism (VTE). VTE occurs at a rate of 1/1000 in the general population1 and significantly increases with age, especially after age 60, with rates as high as 1/100.2 Duplex ultrasonography has largely replaced venography as the diagnostic test of choice for deep venous thrombosis (DVT),3 and spiral CT pulmonary angiography is rapidly replacing ventilation/perfusion lung scans as the diagnostic test of choice for pulmonary embolism (PE).4 Multiple agents are now available for the initial treatment of VTE including unfractionated heparin, low-molecular-weight heparin, and fondaparinux,5 and although the vitamin K antagonists remain the sole oral agents for the long-term treatment of VTE, new oral alternatives are on the horizon.6 As the result of large randomized controlled trials the secondary prevention of recurrent VTE has improved, with the duration of therapy now based on an understanding of the initial inciting event and the presence of ongoing risk factors.7 Patients with idiopathic DVT or persistent risk factors require anticoagulant therapy for a minimum of 6 months, and more likely, ≥12 months, with a cumulative risk of recurrence as high as 30% at 8 years.8 For patients with cancer and VTE, it has been shown that therapy with low-molecular-weight heparin for the first 3 to 6 months results in better outcomes than the outcomes of patients transitioned to warfarin early in the course of therapy.9 Unfortunately, the application of vena cava interruption has not undergone the same robust scrutiny as have other therapeutic interventions, and consequently our knowledge of when and how to use inferior vena cava (IVC) interruption is limited. That is, until now.See p 416The idea that interrupting flow in the IVC is a reasonable and tolerable means of preventing PE began >50 years ago, first with ligation or plication techniques, which then moved into less invasive techniques by percutaneous insertion of filtering devices.10 The use of these devices has increased dramatically during the last 2 decades, with estimates of 2000 being inserted in 1979, which increased to 49 000 in 1999.11 Decousus et al,12 in their long-term study in this issue of Circulation of the comparative outcomes of patients with DVT with or without PE who were treated initially with or without a vena cava filter, have done a great service. They have not only performed the first and only randomized controlled trial of such therapy but also by studying patients for up to 8 years, they have defined the long-term outcome of these patients. Their initial report in 199813 randomized 400 patients to receive either 1 of 4 types of IVC filters with concomitant anticoagulation or anticoagulation alone. At the 2-year follow-up, patients with filters had fewer PE but more DVTs compared with those with anticoagulation alone. Now, at 8 years, even though the total number of VTE events was similar in both groups (36.4% versus 35.4%, filter versus no filter, respectively), those with an IVC filter experienced a greater cumulative incidence of symptomatic DVT (35.7% versus 27.5%; HR 1.52, CI 1.02 to 2.27; P=0.042), but significantly fewer symptomatic pulmonary emboli (6.2% versus 15.1%; HR 0.37, CI 0.17 to 0.79; P=0.008). Of particular note is the finding that the rate of postthrombotic syndrome (70.3% versus 69.7%, HR 0.87; CI 0.66 to 1.13; P=0.30), a complication that may be expected with greater frequency in patients with an IVC filter, was not different between groups. The conclusion from this long-term follow-up was similar to the original report; that is, with an IVC filter there is an equivalent trade-off of fewer PE at the cost of more DVTs, but also there is no difference in long-term morbidity (ie, postthrombotic syndrome) or mortality. Thus, the conclusion that “the systematic use of permanent vena cava filters in the general population with VTE is not recommended” seems justified.What Decousus et al12 have established is that an IVC filter provides no additional net benefit to anticoagulation for the average patient with DVT with or without PE. These patients, however, are not the usual candidates for IVC filter placement. General indications support patients in whom anticoagulants cannot be used or those in whom anticoagulation has failed to prevent recurrent VTE.10,14 Some clinicians also advocate IVC filter placement for primary prophylaxis in patients considered to be at high risk for PE or as prophylaxis in patients with free-floating iliac thrombi. Although this study provides helpful information, it does not address the value of IVC filters versus alternative therapies in these situations in which it is commonly advocated.Finally, the outcomes pertaining to the postthrombotic syndrome and death are not surprising, in that all patients in this study continued on oral anticoagulation for a minimum of 3 months, and 50% of patients were still taking a vitamin K antagonist at the end of 8 years. In addition, 24% of patients on entry to the study already had symptoms of the postthrombotic syndrome, which potentially limited the differences between groups. Would these outcomes be the same if an IVC filter were used without concomitant anticoagulation, the most common situation in which they are used?What conclusions can be drawn from this study, and what questions remain unanswered? We do not know which type of filter is best. We do not know precisely how long anticoagulation should be given, or whether it is necessary, when a filter is inserted.15 Finally, we have not tested in a systematic way the traditional indications for filter use against alternative means of treatment. We do not know whether a filter alone is better or worse than anticoagulation alone in selected patient groups. What we can say with some certainty, as indicated above, is that a vena cava filter does not significantly add protection in addition to anticoagulation in patients with DVT with or without PE. In selected subgroups with a predictably high rate of new or recurrent PE, however, filter placement along with anticoagulation may be of value, as suggested by Decousus et al.12Finally, filter technology has advanced to the point that retrievable filters are available that can be removed several weeks or up to several months after insertion.16 This new technology presents a new set of questions. For instance, because 42% of the pulmonary emboli occurred in the first year of the “no-filter” group as compared with 22% in the “filter” group of the Decousus et al study,12 without a significant difference in recurrent DVT during this interval, temporary filter placement along with anticoagulation may be the optimal intervention. After 3 to 6 months the filter can be removed with continuation of the anticoagulation.The long-term secondary prevention of venous thromboembolism is a story that evolves as new therapeutic agents or interventions enter the playing field. As such, some questions are answered, but new questions arise, and we still have much to learn.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.DisclosureDr Ansell has received research grants from AstraZeneca and Sanofi-Aventis; has served on the Speakers’ Bureaus of or received honoraria from Bristol-Myers Squibb, AstraZeneca, and Sanofi-Aventis; and has served as a consultant or advisory board member for AstraZeneca, St. Jude, and Novartis; however, these relationships do not pose a conflict with regard to the topic of this editorial.FootnotesCorrespondence to Jack Ansell, MD, Dept of Medicine, Boston University School of Medicine, 88 East Newton St, Boston, MA 02118. E-mail [email protected] References 1 Silverstein M, Heit JA, Mohr D, Petterson T, O’Fallon WM, Melton JL. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25 year population based study. Arch Intern Med. 1998; 158: 585–593.CrossrefMedlineGoogle Scholar2 Heit JA. Venous thromboembolism epidemiology: implications for prevention and management. Semin Thromb Hemost. 2002; 28: 3–13.CrossrefMedlineGoogle Scholar3 Kraaijenhagen RA, Lensing AW, Wallis JW, van Beek EJ, ten Cate JW, Buller HR. Diagnostic management of venous thromboembolism. In: Pineo GF, Hull RD, eds. Bailliere’s Clinical Haematology, Prevention, Diagnosis and Management of Venous Thromboembolic Disease, Vol 11. London, UK: Bailliere Tindall; 1998: 541–586.Google Scholar4 Moores LK, Jackson WL, Shorr AF, Jackson JL. Meta-analysis: outcomes in patients with suspected pulmonary embolism managed with computed tomographic pulmonary angiography. Ann Intern Med. 2004; 141: 866–874.CrossrefMedlineGoogle Scholar5 Hirsh J, Raschke R. Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004; 126: 188S–203S.CrossrefMedlineGoogle Scholar6 Weitz JI, Hirsh J, Samama MM. New anticoagulant drugs: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004; 126: 265S–286S.CrossrefMedlineGoogle Scholar7 Buller HR, Agnelli G, Hull RD, Hyers TM, Prins MH, Raskob GE. Antithrombotic therapy for venous thromboembolic disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004; 126: 401S–428S.CrossrefMedlineGoogle Scholar8 Prandoni P, Lensing AWA, Cogo A, Cuppini S, Villalta S, Carta M, Cattelan AM, Polistena P, Bernardi E, Prins MH. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996; 125: 1–7.CrossrefMedlineGoogle Scholar9 Lee A, Levine M, Baker R, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M; CLOT Investigators. Low molecular weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003; 349: 146–153.CrossrefMedlineGoogle Scholar10 Greenfield LJ. Indications and efficacy of vena caval filters. In: Bergqvist D, Comerota AJ, Nicolaides AN, Scurr JH, eds. Prevention of Venous Thromboembolism. London, UK: Med-Orion Publishing; 1994: 393–404.Google Scholar11 Stein PD, Kayali F, Olson RE. Twenty-one year trends in the use of inferior vena cava filters. Arch Intern Med. 2004; 164: 1541–1545.CrossrefMedlineGoogle Scholar12 The PREPIC Study Group. Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prévention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study. Circulation. 2005; 112: 416–422.LinkGoogle Scholar13 Decousus H, Leizorovicz A, Parent F, Page Y, Tardy B, Girard P, Laporte S, Faivre R, Charbonnier B, Barral FG, Huet Y, Simonneau G. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis. N Engl J Med. 1998; 338: 409–415.CrossrefMedlineGoogle Scholar14 Streiff MB. Vena caval filters: a comprehensive review. Blood. 2000; 95: 3669–3677.CrossrefMedlineGoogle Scholar15 Gomes MPV, Kaplan KL, Deitcher ST. Patients with inferior vena caval filters should receive chronic thromboprophylaxis. Med Clin N Am. 2003; 87: 1189–1203.CrossrefMedlineGoogle Scholar16 Stein PD, Alnas M, Skaf E, Kayali F, Siddiqui T, Olson RE, Patel K. Outcome and complications of retrievable inferior vena cava filters. Am J Cardiol. 2004; 94: 1090–1093.CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Stewart M and Jenkins J (2018) Inferior Vena Cava Filters Endovascular Interventions, 10.1002/9781119283539.ch23, (275-289), Online publication date: 3-Dec-2018. Sharma R (2017) It is not necessary to use both an IVC filter and anticoagulation therapy for severe pulmonary embolism, Clinical Research In Practice: The Journal of Team Hippocrates, 10.22237/crp/1498867560, 3:2 (2016) Vena cava filters Pulmonary Embolism, 10.1002/9781119039112.ch117, (597-614) Zhang F, Li D, Liu J and Zhang H (2015) The Vena Tech LP Permanent Caval Filter: Effectiveness and Safety in the Clinical Setting in Three Chinese Medical Centers, Thrombosis Research, 10.1016/j.thromres.2015.04.015, 136:1, (40-44), Online publication date: 1-Jul-2015. Sebunya J, Baschera D, Isenegger P and Zellweger R (2011) Optional inferior vena cava filter use in surgical patients: a Western Australian experience, ANZ Journal of Surgery, 10.1111/j.1445-2197.2010.05636.x, 81:11, (804-809), Online publication date: 1-Nov-2011. McIntyre L and Langdale L (2010) Pulmonary Embolism Critical Care Surgery, 10.1007/978-1-84996-378-7_10, (157-171), . Kaufman J, Rundback J, Kee S, Geerts W, Gillespie D, Kahn S, Kearon C, Rectenwald J, Rogers F, Stavropoulos S, Streiff M, Vedantham S and Venbrux A (2009) Development of a Research Agenda for Inferior Vena Cava Filters: Proceedings from a Multidisciplinary Research Consensus Panel, Journal of Vascular and Interventional Radiology, 10.1016/j.jvir.2009.03.007, 20:6, (697-707), Online publication date: 1-Jun-2009. SINGH P, LAI H, LERNER R, CHUGH T and ARONOW W (2009) Guidelines and the use of inferior vena cava filters: a review of an institutional experience, Journal of Thrombosis and Haemostasis, 10.1111/j.1538-7836.2008.03217.x, 7:1, (65-71), Online publication date: 1-Jan-2009. McIntyre L and Langdale L (2009) Pulmonary Embolism General Surgery, 10.1007/978-1-84628-833-3_25, (263-272), . Light E, Angle J and Smith S Real-time 3-D ultrasound guidance of interventional devices, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 10.1109/TUFFC.898, 55:9, (2066-2078) Fox M and Kahn S (2008) Postthrombotic Syndrome in Relation to Vena Cava Filter Placement: A Systematic Review, Journal of Vascular and Interventional Radiology, 10.1016/j.jvir.2008.03.022, 19:7, (981-985.e3), Online publication date: 1-Jul-2008. Janjigian M and Muhs B (2008) Current Treatment of Acute Lower Extremity Deep Venous Thrombosis, The International Journal of Lower Extremity Wounds, 10.1177/1534734608314566, 7:1, (15-20), Online publication date: 1-Mar-2008. Ray C and Prochazka A (2007) The Need for Anticoagulation Following Inferior Vena Cava Filter Placement: Systematic Review, CardioVascular and Interventional Radiology, 10.1007/s00270-007-9244-x, 31:2, (316-324), Online publication date: 1-Mar-2008. Light E and Smith S (2007) 9F-5 Combined 2D Array Transducers/Deployment Kits for Real-Time 3D Ultrasound Guidance of Interventional Devices 2007 IEEE Ultrasonics Symposium Proceedings, 10.1109/ULTSYM.2007.216, 978-1-4244-1383-6, (844-847) BILLETT H, JACOBS L, MADSEN E, GIANNATTASIO E, MAHESH S and COHEN H (2007) Efficacy of inferior vena cava filters in anticoagulated patients, Journal of Thrombosis and Haemostasis, 10.1111/j.1538-7836.2007.02668.x, 5:9, (1848-1853), Online publication date: 1-Sep-2007. Bressollette L (2005) , Journal des Maladies Vasculaires, 10.1016/S0398-0499(05)83852-1, 30:5, (306), Online publication date: 1-Dec-2005. July 19, 2005Vol 112, Issue 3 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.105.547828PMID: 16027267 Originally publishedJuly 19, 2005 Keywordsvena caval filtersthrombosisanticoagulantsEditorialsPDF download Advertisement" @default.
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