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• W2043928897 abstract "Melatonin exerts oncostatic effects on different kinds of tumors, especially on hormone-dependent breast cancer. The general conclusion is that melatonin, in vivo, reduces the incidence and growth of chemically-induced mammary tumors in rodents, and, in vitro, inhibits the proliferation and invasiveness of human breast cancer cells. Both studies support the hypothesis that melatonin inhibits the growth of breast cancer by interacting with estrogen-signaling pathways through three different mechanisms: (a) the indirect neuroendocrine mechanism which includes the melatonin downregulation of the hypothalamic-pituitary-reproductive axis and the consequent reduction of circulating levels of gonadal estrogens, (b) direct melatonin actions at tumor cell level by interacting with the activation of the estrogen receptor, thus behaving as a selective estrogen receptor modulator (SERM), and (c) the regulation of the enzymes involved in the biosynthesis of estrogens in peripheral tissues, thus behaving as a selective estrogen enzyme modulator (SEEM). As melatonin reduces the activity and expression of aromatase, sulfatase and 17β-hydroxysteroid dehydrogenase and increases the activity and expression of estrogen sulfotransferase, it may protect mammary tissue from excessive estrogenic effects. Thus, a single molecule has both SERM and SEEM properties, one of the main objectives desired for the breast antitumoral drugs. Since the inhibition of enzymes involved in the biosynthesis of estrogens is currently one of the first therapeutic strategies used against the growth of breast cancer, melatonin modulation of different enzymes involved in the synthesis of steroid hormones makes, collectively, this indolamine an interesting anticancer drug in the prevention and treatment of estrogen-dependent mammary tumors. Keywords: Melatonin, pineal gland, breast cancer, estradiol, aromatase, sulfatase, sulfotransferase, 17β-hydroxysteroid dehydrogenase" @default.
• W2043928897 created "2016-06-24" @default.
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• W2043928897 date "2008-12-01" @default.
• W2043928897 modified "2023-10-18" @default.
• W2043928897 title "Melatonin as a Selective Estrogen Enzyme Modulator" @default.
• W2043928897 cites W1495111481 @default.
• W2043928897 cites W1572500512 @default.
• W2043928897 cites W1594539812 @default.
• W2043928897 cites W1655441320 @default.
• W2043928897 cites W1712951338 @default.
• W2043928897 cites W1972069681 @default.
• W2043928897 cites W1973352944 @default.
• W2043928897 cites W1975192192 @default.
• W2043928897 cites W1976645048 @default.
• W2043928897 cites W1979805239 @default.
• W2043928897 cites W1980544171 @default.
• W2043928897 cites W1981516830 @default.
• W2043928897 cites W1983251875 @default.
• W2043928897 cites W1985577941 @default.
• W2043928897 cites W1988241394 @default.
• W2043928897 cites W1992378219 @default.
• W2043928897 cites W1994710209 @default.
• W2043928897 cites W2002061397 @default.
• W2043928897 cites W2006000722 @default.
• W2043928897 cites W2011192675 @default.
• W2043928897 cites W2012901315 @default.
• W2043928897 cites W2013936099 @default.
• W2043928897 cites W2016868037 @default.
• W2043928897 cites W2024268846 @default.
• W2043928897 cites W2028085265 @default.
• W2043928897 cites W2031921473 @default.
• W2043928897 cites W2033737465 @default.
• W2043928897 cites W2036402179 @default.
• W2043928897 cites W2038491937 @default.
• W2043928897 cites W2042075671 @default.
• W2043928897 cites W2042288645 @default.
• W2043928897 cites W2043652540 @default.
• W2043928897 cites W2043816199 @default.
• W2043928897 cites W2045531839 @default.
• W2043928897 cites W2053397270 @default.
• W2043928897 cites W2070426331 @default.
• W2043928897 cites W2076956409 @default.
• W2043928897 cites W2076977446 @default.
• W2043928897 cites W2078655231 @default.
• W2043928897 cites W2080191063 @default.
• W2043928897 cites W2081129926 @default.
• W2043928897 cites W2084157491 @default.
• W2043928897 cites W2091340779 @default.
• W2043928897 cites W2094654195 @default.
• W2043928897 cites W2095146465 @default.
• W2043928897 cites W2102922803 @default.
• W2043928897 cites W2103204018 @default.
• W2043928897 cites W2103885797 @default.
• W2043928897 cites W2104432827 @default.
• W2043928897 cites W2109525253 @default.
• W2043928897 cites W2110433560 @default.
• W2043928897 cites W2114718669 @default.
• W2043928897 cites W2115789575 @default.
• W2043928897 cites W2120854324 @default.
• W2043928897 cites W2122476299 @default.
• W2043928897 cites W2130996329 @default.
• W2043928897 cites W2134700543 @default.
• W2043928897 cites W2136052981 @default.
• W2043928897 cites W2136061004 @default.
• W2043928897 cites W2137255754 @default.
• W2043928897 cites W2139034458 @default.
• W2043928897 cites W2141293774 @default.
• W2043928897 cites W2143583425 @default.
• W2043928897 cites W2147124650 @default.
• W2043928897 cites W2148317166 @default.
• W2043928897 cites W2149594380 @default.
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• W2043928897 cites W2156261924 @default.
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• W2043928897 cites W2171853178 @default.
• W2043928897 cites W2285947158 @default.
• W2043928897 cites W2320413839 @default.
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• W2043928897 doi "https://doi.org/10.2174/156800908786733469" @default.
• W2043928897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19075592" @default.
• W2043928897 hasPublicationYear "2008" @default.
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