FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043930109> ?p ?o ?g. }

• W2043930109 endingPage "144" @default.
• W2043930109 startingPage "134" @default.
• W2043930109 abstract "Neuronal glucose uptake was thought to be independent of insulin, being facilitated by glucose transporters GLUT1 and GLUT3, which do not require insulin signaling. However, it is now known that components of the insulin-mediated glucose uptake pathway, including neuronal insulin synthesis and the insulin-dependent glucose transporter GLUT4, are present in brain tissue, particularly in the hippocampus. There is considerable recent evidence that insulin signaling is crucial to optimal hippocampal function. The physiological basis, however, is not clear. We propose that while noninsulin-dependent GLUT1 and GLUT3 transport is adequate for resting needs, the surge in energy use during sustained cognitive activity requires the additional induction of insulin-signaled GLUT4 transport. We studied hippocampal high-energy phosphate metabolism in eight healthy volunteers, using a lipid infusion protocol to inhibit insulin signaling. Contrary to conventional wisdom, it is now known that free fatty acids do cross the blood-brain barrier in significant amounts. Energy metabolism within the hippocampus was assessed during standardized cognitive activity. (31)Phosphorus magnetic resonance spectroscopy was used to determine the phosphocreatine (PCr)-to-adenosine triphosphate (ATP) ratio. This ratio reflects cellular energy production in relation to concurrent cellular energy expenditure. With lipid infusion, the ratio was significantly reduced during cognitive activity (PCr/ATP 1.0 ± 0.4 compared with 1.4 ± 0.4 before infusion, P = 0.01). Without lipid infusion, there was no reduction in the ratio during cognitive activity (PCr/ATP 1.5 ± 0.3 compared with 1.4 ± 0.4, P = 0.57). This provides supporting evidence for a physiological role for insulin signaling in facilitating increased neuronal glucose uptake during sustained cognitive activity. Loss of this response, as may occur in type 2 diabetes, would lead to insufficient neuronal energy availability during cognitive activity." @default.
• W2043930109 created "2016-06-24" @default.
• W2043930109 creator A5022580654 @default.
• W2043930109 creator A5022593647 @default.
• W2043930109 creator A5032891489 @default.
• W2043930109 creator A5070743850 @default.
• W2043930109 creator A5088727635 @default.
• W2043930109 creator A5090998379 @default.
• W2043930109 date "2013-02-15" @default.
• W2043930109 modified "2023-09-26" @default.
• W2043930109 title "Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance" @default.
• W2043930109 cites W125544719 @default.
• W2043930109 cites W1551443142 @default.
• W2043930109 cites W1565240736 @default.
• W2043930109 cites W1590376803 @default.
• W2043930109 cites W1819107323 @default.
• W2043930109 cites W1838170839 @default.
• W2043930109 cites W1969889278 @default.
• W2043930109 cites W1971911315 @default.
• W2043930109 cites W1975699010 @default.
• W2043930109 cites W1978248654 @default.
• W2043930109 cites W1978808714 @default.
• W2043930109 cites W1981741821 @default.
• W2043930109 cites W1989571923 @default.
• W2043930109 cites W1990020089 @default.
• W2043930109 cites W1992431456 @default.
• W2043930109 cites W1993303421 @default.
• W2043930109 cites W1995357799 @default.
• W2043930109 cites W2012898950 @default.
• W2043930109 cites W2014788105 @default.
• W2043930109 cites W2016764251 @default.
• W2043930109 cites W2025642774 @default.
• W2043930109 cites W2027162538 @default.
• W2043930109 cites W2027585354 @default.
• W2043930109 cites W2029906937 @default.
• W2043930109 cites W2037427415 @default.
• W2043930109 cites W2043498565 @default.
• W2043930109 cites W2044832776 @default.
• W2043930109 cites W2049871798 @default.
• W2043930109 cites W2050154889 @default.
• W2043930109 cites W2055908419 @default.
• W2043930109 cites W2057702509 @default.
• W2043930109 cites W2062229924 @default.
• W2043930109 cites W2062354481 @default.
• W2043930109 cites W2066736958 @default.
• W2043930109 cites W2067902437 @default.
• W2043930109 cites W2068205637 @default.
• W2043930109 cites W2070900312 @default.
• W2043930109 cites W2092483015 @default.
• W2043930109 cites W2095187162 @default.
• W2043930109 cites W2095260583 @default.
• W2043930109 cites W2101129883 @default.
• W2043930109 cites W2106852380 @default.
• W2043930109 cites W2107135340 @default.
• W2043930109 cites W2111631797 @default.
• W2043930109 cites W2115433418 @default.
• W2043930109 cites W2120282127 @default.
• W2043930109 cites W2124508932 @default.
• W2043930109 cites W2126317966 @default.
• W2043930109 cites W2127096777 @default.
• W2043930109 cites W2127575529 @default.
• W2043930109 cites W2142240447 @default.
• W2043930109 cites W2159000141 @default.
• W2043930109 cites W2169709509 @default.
• W2043930109 cites W2183659943 @default.
• W2043930109 cites W4234731337 @default.
• W2043930109 doi "https://doi.org/10.1002/brb3.124" @default.
• W2043930109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3607154" @default.
• W2043930109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23533158" @default.
• W2043930109 hasPublicationYear "2013" @default.
• W2043930109 type Work @default.
• W2043930109 sameAs 2043930109 @default.
• W2043930109 citedByCount "36" @default.
• W2043930109 countsByYear W20439301092013 @default.
• W2043930109 countsByYear W20439301092014 @default.
• W2043930109 countsByYear W20439301092015 @default.
• W2043930109 countsByYear W20439301092016 @default.
• W2043930109 countsByYear W20439301092017 @default.
• W2043930109 countsByYear W20439301092018 @default.
• W2043930109 countsByYear W20439301092019 @default.
• W2043930109 countsByYear W20439301092020 @default.
• W2043930109 countsByYear W20439301092021 @default.
• W2043930109 countsByYear W20439301092022 @default.
• W2043930109 countsByYear W20439301092023 @default.
• W2043930109 crossrefType "journal-article" @default.
• W2043930109 hasAuthorship W2043930109A5022580654 @default.
• W2043930109 hasAuthorship W2043930109A5022593647 @default.
• W2043930109 hasAuthorship W2043930109A5032891489 @default.
• W2043930109 hasAuthorship W2043930109A5070743850 @default.
• W2043930109 hasAuthorship W2043930109A5088727635 @default.
• W2043930109 hasAuthorship W2043930109A5090998379 @default.
• W2043930109 hasBestOaLocation W20439301091 @default.
• W2043930109 hasConcept C112446052 @default.
• W2043930109 hasConcept C126322002 @default.
• W2043930109 hasConcept C134018914 @default.
• W2043930109 hasConcept C161573976 @default.
• W2043930109 hasConcept C17093226 @default.
• W2043930109 hasConcept C185592680 @default.

• next