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• W2043930283 abstract "Proteasome assembling chaperone (PAC) 3 acts as a homodimer and plays an important role in proteasome formation. We screened JBIR-22 (1) as an inhibitor for protein-protein interaction (PPI) of PAC3 homodimer from our natural product library using a protein fragment complementation assay (PCA) with monomeric Kusabira-Green fluorescent protein (mKG) in vitro and found that 1 exhibited potent inhibitory activity against PAC3 homodimerization. Compound 1 showed long-term cytotoxicity against the human cervical carcinoma cell line, HeLa. This is the first report of a PPI inhibitor for proteasome assembly factors." @default.
• W2043930283 created "2016-06-24" @default.
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• W2043930283 date "2010-02-24" @default.
• W2043930283 modified "2023-09-27" @default.
• W2043930283 title "JBIR-22, An Inhibitor for Protein−Protein Interaction of the Homodimer of Proteasome Assembly Factor 3" @default.
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• W2043930283 doi "https://doi.org/10.1021/np900788e" @default.
• W2043930283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20180542" @default.
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