FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043931318> ?p ?o ?g. }

• W2043931318 endingPage "418" @default.
• W2043931318 startingPage "412" @default.
• W2043931318 abstract "Transplantation Centers using human cytomegalovirus (HCMV) antigenemia-based preemptive therapy will need to replace in the near future the antigenemia assay with a more standardized and automatable assay, such as a molecular assay quantifying HCMV DNA in blood (DNAemia). Thus, in view of replacing antigenemia with clinically safe cutoff values, DNAemia levels corresponding to antigenemia cutoffs guiding HCMV preemptive therapy were determined retrospectively in solid organ and hematopoietic stem cell transplant recipients (HSCTR) using an “in-house” quantitative PCR (QPCR) method. Since preemptive therapy had prevented appearance of HCMV disease in all patients tested, DNA cutoffs determined retrospectively had to be considered as safe clinically as antigenemia cutoffs used prospectively. However, in solid organ transplant recipients (SOTR), initiating preemptive therapy upon an antigenemia cutoff of 100 pp65-positive leukocytes, a DNAemia cutoff of 300,000 copies/ml blood had positive and negative predictive values of >90%, indicating that a DNAemia cutoff could achieve, in terms of prevention of HCMV disease, the same clinical results as the antigenemia cutoff. In HSCTR, initiating preemptive therapy upon first antigenemia positivity, a DNAemia cutoff of 10,000 copies/ml blood had a positive predictive value of >90%, indicating that the great majority of patients treated under the antigenemia guidance would have been treated also using this DNA cutoff. On the other hand, the negative predictive value of 28.6% indicated that two out of three HSCTR had been treated under the antigenemia guidance having the same levels of viral DNA as the untreated patients. The data suggest that a quantitative cutoff could be adopted as a guiding criterion for preemptive therapy also in HSCTR. Regression analysis allowed to determine the DNAemia (corresponding to QPCR) cutoff values for two commercial assays tested both in solid organ and HSCTR. Retrospective DNAemia cutoff values will be verified for safety in prospective trials. J. Med. Virol. 73:412–418, 2004. © 2004 Wiley-Liss, Inc." @default.
• W2043931318 created "2016-06-24" @default.
• W2043931318 creator A5013261663 @default.
• W2043931318 creator A5025908349 @default.
• W2043931318 creator A5041843332 @default.
• W2043931318 creator A5064787650 @default.
• W2043931318 creator A5069668709 @default.
• W2043931318 creator A5072145698 @default.
• W2043931318 creator A5077242229 @default.
• W2043931318 creator A5079297350 @default.
• W2043931318 date "2004-01-01" @default.
• W2043931318 modified "2023-10-14" @default.
• W2043931318 title "Clinically-based determination of safe DNAemia cutoff levels for preemptive therapy or human cytomegalovirus infections in solid organ and hematopoietic stem cell transplant recipients" @default.
• W2043931318 cites W1564109452 @default.
• W2043931318 cites W1955863325 @default.
• W2043931318 cites W1966574164 @default.
• W2043931318 cites W1967480818 @default.
• W2043931318 cites W1976867218 @default.
• W2043931318 cites W2000702525 @default.
• W2043931318 cites W2005679373 @default.
• W2043931318 cites W2028103994 @default.
• W2043931318 cites W2029929699 @default.
• W2043931318 cites W2066722646 @default.
• W2043931318 cites W2072693747 @default.
• W2043931318 cites W2084628297 @default.
• W2043931318 cites W2093573397 @default.
• W2043931318 cites W2094198098 @default.
• W2043931318 cites W2095881805 @default.
• W2043931318 cites W2096159869 @default.
• W2043931318 cites W2102478653 @default.
• W2043931318 cites W2103386912 @default.
• W2043931318 cites W2111275795 @default.
• W2043931318 cites W211436638 @default.
• W2043931318 cites W2117936700 @default.
• W2043931318 cites W2118597625 @default.
• W2043931318 cites W2131091524 @default.
• W2043931318 cites W2133043538 @default.
• W2043931318 cites W2136497987 @default.
• W2043931318 cites W2146446395 @default.
• W2043931318 cites W2154384598 @default.
• W2043931318 cites W2168876359 @default.
• W2043931318 cites W2169086958 @default.
• W2043931318 cites W2315317361 @default.
• W2043931318 cites W4238234042 @default.
• W2043931318 doi "https://doi.org/10.1002/jmv.20107" @default.
• W2043931318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15170637" @default.
• W2043931318 hasPublicationYear "2004" @default.
• W2043931318 type Work @default.
• W2043931318 sameAs 2043931318 @default.
• W2043931318 citedByCount "38" @default.
• W2043931318 countsByYear W20439313182012 @default.
• W2043931318 countsByYear W20439313182013 @default.
• W2043931318 countsByYear W20439313182014 @default.
• W2043931318 countsByYear W20439313182015 @default.
• W2043931318 countsByYear W20439313182016 @default.
• W2043931318 countsByYear W20439313182018 @default.
• W2043931318 countsByYear W20439313182019 @default.
• W2043931318 crossrefType "journal-article" @default.
• W2043931318 hasAuthorship W2043931318A5013261663 @default.
• W2043931318 hasAuthorship W2043931318A5025908349 @default.
• W2043931318 hasAuthorship W2043931318A5041843332 @default.
• W2043931318 hasAuthorship W2043931318A5064787650 @default.
• W2043931318 hasAuthorship W2043931318A5069668709 @default.
• W2043931318 hasAuthorship W2043931318A5072145698 @default.
• W2043931318 hasAuthorship W2043931318A5077242229 @default.
• W2043931318 hasAuthorship W2043931318A5079297350 @default.
• W2043931318 hasBestOaLocation W20439313182 @default.
• W2043931318 hasConcept C121332964 @default.
• W2043931318 hasConcept C126322002 @default.
• W2043931318 hasConcept C159047783 @default.
• W2043931318 hasConcept C203014093 @default.
• W2043931318 hasConcept C2522874641 @default.
• W2043931318 hasConcept C2776409557 @default.
• W2043931318 hasConcept C2777408962 @default.
• W2043931318 hasConcept C2777662283 @default.
• W2043931318 hasConcept C2777732132 @default.
• W2043931318 hasConcept C2778217198 @default.
• W2043931318 hasConcept C2779820661 @default.
• W2043931318 hasConcept C2780727368 @default.
• W2043931318 hasConcept C2911091166 @default.
• W2043931318 hasConcept C2993512173 @default.
• W2043931318 hasConcept C3020491458 @default.
• W2043931318 hasConcept C62520636 @default.
• W2043931318 hasConcept C71924100 @default.
• W2043931318 hasConcept C90924648 @default.
• W2043931318 hasConceptScore W2043931318C121332964 @default.
• W2043931318 hasConceptScore W2043931318C126322002 @default.
• W2043931318 hasConceptScore W2043931318C159047783 @default.
• W2043931318 hasConceptScore W2043931318C203014093 @default.
• W2043931318 hasConceptScore W2043931318C2522874641 @default.
• W2043931318 hasConceptScore W2043931318C2776409557 @default.
• W2043931318 hasConceptScore W2043931318C2777408962 @default.
• W2043931318 hasConceptScore W2043931318C2777662283 @default.
• W2043931318 hasConceptScore W2043931318C2777732132 @default.
• W2043931318 hasConceptScore W2043931318C2778217198 @default.
• W2043931318 hasConceptScore W2043931318C2779820661 @default.
• W2043931318 hasConceptScore W2043931318C2780727368 @default.
• W2043931318 hasConceptScore W2043931318C2911091166 @default.

• next