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- W2043933337 abstract "Bopindolol is a new non-selective β-blocker with a prolonged duration of action and mild intrinsic sympathomimetic activity. In order to assess its influence on quality of life, 162 hypertensive patients were treated in a 4-week randomized, double-blind, controlled trial. After a 2-week placebo washout period patients with a supine diastolic blood pressure of ≥100mmHg were randomly allocated to either 0.05 mg bopindolol as 'active' placebo or 0.5, 1 or 2 mg bopindolol daily. After 4 weeks of treatment normalization rates (blood pressure ≤90–95 mmHg, the higher level corresponding to a higher pretreatment level) were 23.7% with 0.05 mg bopindolol and 32.5, 67.5 and 64.1% with 0.5, 1 or 2 mg bopindolol, respectively. Quality of life was evaluated through the Nurnberger-Alters-Selbstbeurteilungs-Skala test, which evaluates life satisfaction, social participation, sleep dysfunction, mental and physical performance, and mood. Therapy with bopindolol exerted a significant positive impact on these dimensions. Adverse events were rare and regressive during active therapy." @default.
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- W2043933337 date "1988-01-01" @default.
- W2043933337 modified "2023-09-26" @default.
- W2043933337 title "Quality of life as a dimension in drug development" @default.
- W2043933337 doi "https://doi.org/10.1097/00001573-198801002-00010" @default.
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