FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043937578> ?p ?o ?g. }

• W2043937578 endingPage "2233" @default.
• W2043937578 startingPage "2224" @default.
• W2043937578 abstract "LMO2 and LMO4 are members of a small family of nuclear transcriptional regulators that are important for both normal development and disease processes. LMO2 is essential for hemopoiesis and angiogenesis, and inappropriate overexpression of this protein leads to T-cell leukemias. LMO4 is developmentally regulated in the mammary gland and has been implicated in breast oncogenesis. Both proteins comprise two tandemly repeated LIM domains. LMO2 and LMO4 interact with the ubiquitous nuclear adaptor protein ldb1/NLI/CLIM2, which associates with the LIM domains of LMO and LIM homeodomain proteins via its LIM interaction domain (ldb1-LID). We report the solution structures of two LMO:ldb1 complexes (PDB: 1M3V and 1J2O) and show that ldb1-LID binds to the N-terminal LIM domain (LIM1) of LMO2 and LMO4 in an extended conformation, contributing a third strand to a beta-hairpin in LIM1 domains. These findings constitute the first molecular definition of LIM-mediated protein-protein interactions and suggest a mechanism by which ldb1 can bind a variety of LIM domains that share low sequence homology." @default.
• W2043937578 created "2016-06-24" @default.
• W2043937578 creator A5013309333 @default.
• W2043937578 creator A5033787418 @default.
• W2043937578 creator A5044924074 @default.
• W2043937578 creator A5052093614 @default.
• W2043937578 creator A5052774681 @default.
• W2043937578 creator A5074575943 @default.
• W2043937578 date "2003-05-01" @default.
• W2043937578 modified "2023-10-02" @default.
• W2043937578 title "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4" @default.
• W2043937578 cites W1539339671 @default.
• W2043937578 cites W1589295940 @default.
• W2043937578 cites W1804317820 @default.
• W2043937578 cites W1975459052 @default.
• W2043937578 cites W1979251604 @default.
• W2043937578 cites W1980344333 @default.
• W2043937578 cites W1982746675 @default.
• W2043937578 cites W1986625228 @default.
• W2043937578 cites W1995017064 @default.
• W2043937578 cites W1997366921 @default.
• W2043937578 cites W2000054590 @default.
• W2043937578 cites W2002195659 @default.
• W2043937578 cites W2004945062 @default.
• W2043937578 cites W2008117836 @default.
• W2043937578 cites W2008708467 @default.
• W2043937578 cites W2010035436 @default.
• W2043937578 cites W2011115644 @default.
• W2043937578 cites W2018891862 @default.
• W2043937578 cites W2029676157 @default.
• W2043937578 cites W2033764784 @default.
• W2043937578 cites W2048105999 @default.
• W2043937578 cites W2052606462 @default.
• W2043937578 cites W2052933818 @default.
• W2043937578 cites W2064811219 @default.
• W2043937578 cites W2067041186 @default.
• W2043937578 cites W2077743844 @default.
• W2043937578 cites W2078597493 @default.
• W2043937578 cites W2083773716 @default.
• W2043937578 cites W2084949662 @default.
• W2043937578 cites W2088430517 @default.
• W2043937578 cites W2089881094 @default.
• W2043937578 cites W2099704043 @default.
• W2043937578 cites W2111942728 @default.
• W2043937578 cites W2112103709 @default.
• W2043937578 cites W2113485452 @default.
• W2043937578 cites W2129879061 @default.
• W2043937578 cites W2140998261 @default.
• W2043937578 cites W2162362489 @default.
• W2043937578 cites W2170291310 @default.
• W2043937578 cites W2170957485 @default.
• W2043937578 cites W2230550799 @default.
• W2043937578 cites W2320789434 @default.
• W2043937578 doi "https://doi.org/10.1093/emboj/cdg196" @default.
• W2043937578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/156068" @default.
• W2043937578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12727888" @default.
• W2043937578 hasPublicationYear "2003" @default.
• W2043937578 type Work @default.
• W2043937578 sameAs 2043937578 @default.
• W2043937578 citedByCount "66" @default.
• W2043937578 countsByYear W20439375782012 @default.
• W2043937578 countsByYear W20439375782013 @default.
• W2043937578 countsByYear W20439375782014 @default.
• W2043937578 countsByYear W20439375782015 @default.
• W2043937578 countsByYear W20439375782016 @default.
• W2043937578 countsByYear W20439375782017 @default.
• W2043937578 countsByYear W20439375782018 @default.
• W2043937578 countsByYear W20439375782019 @default.
• W2043937578 countsByYear W20439375782021 @default.
• W2043937578 countsByYear W20439375782022 @default.
• W2043937578 crossrefType "journal-article" @default.
• W2043937578 hasAuthorship W2043937578A5013309333 @default.
• W2043937578 hasAuthorship W2043937578A5033787418 @default.
• W2043937578 hasAuthorship W2043937578A5044924074 @default.
• W2043937578 hasAuthorship W2043937578A5052093614 @default.
• W2043937578 hasAuthorship W2043937578A5052774681 @default.
• W2043937578 hasAuthorship W2043937578A5074575943 @default.
• W2043937578 hasBestOaLocation W20439375782 @default.
• W2043937578 hasConcept C104317684 @default.
• W2043937578 hasConcept C183786373 @default.
• W2043937578 hasConcept C24284526 @default.
• W2043937578 hasConcept C29512474 @default.
• W2043937578 hasConcept C5432534 @default.
• W2043937578 hasConcept C54355233 @default.
• W2043937578 hasConcept C62478195 @default.
• W2043937578 hasConcept C86339819 @default.
• W2043937578 hasConcept C86803240 @default.
• W2043937578 hasConcept C94966510 @default.
• W2043937578 hasConcept C95444343 @default.
• W2043937578 hasConceptScore W2043937578C104317684 @default.
• W2043937578 hasConceptScore W2043937578C183786373 @default.
• W2043937578 hasConceptScore W2043937578C24284526 @default.
• W2043937578 hasConceptScore W2043937578C29512474 @default.
• W2043937578 hasConceptScore W2043937578C5432534 @default.
• W2043937578 hasConceptScore W2043937578C54355233 @default.
• W2043937578 hasConceptScore W2043937578C62478195 @default.
• W2043937578 hasConceptScore W2043937578C86339819 @default.
• W2043937578 hasConceptScore W2043937578C86803240 @default.

• next