FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043938659> ?p ?o ?g. }

• W2043938659 endingPage "2954" @default.
• W2043938659 startingPage "2951" @default.
• W2043938659 abstract "This study explores the possible use of reactive oxygen-activated DNA modifying agents against acute myeloid leukemia (AML). A key amine on the lead agent was investigated via cytotoxicity assays and was found necessary for potency. The two best compounds were screened via the NCI-60 cell panel. These two compounds had potency between 200 and 800 nM against many of the leukemia cancer cell types. Subsequent experiments explored activity against a transformed AML model that mimics the molecular signatures identified in primary AML patient samples. A lead compound had an IC50 of 760 nM against this AML cell line as well as a therapeutic index of 7.7 ± 3 between the transformed AML model cell line and non-cancerous human CD34+ blood stem/progenitor cells (UCB). The selectivity was much greater than the mainstays of AML treatment: doxorubicin and cytarabine. This manuscript demonstrates that this novel type of agent may be useful against AML." @default.
• W2043938659 created "2016-06-24" @default.
• W2043938659 creator A5000842818 @default.
• W2043938659 creator A5006022002 @default.
• W2043938659 creator A5016359984 @default.
• W2043938659 creator A5019734419 @default.
• W2043938659 creator A5066624254 @default.
• W2043938659 creator A5076088772 @default.
• W2043938659 creator A5089946751 @default.
• W2043938659 date "2013-05-01" @default.
• W2043938659 modified "2023-09-27" @default.
• W2043938659 title "Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia" @default.
• W2043938659 cites W1534849470 @default.
• W2043938659 cites W1966427351 @default.
• W2043938659 cites W1968142217 @default.
• W2043938659 cites W1969488899 @default.
• W2043938659 cites W1971585520 @default.
• W2043938659 cites W1972779889 @default.
• W2043938659 cites W1982330633 @default.
• W2043938659 cites W1982791774 @default.
• W2043938659 cites W1984046303 @default.
• W2043938659 cites W1984209370 @default.
• W2043938659 cites W1984649994 @default.
• W2043938659 cites W1993238109 @default.
• W2043938659 cites W1997153836 @default.
• W2043938659 cites W2040699335 @default.
• W2043938659 cites W2046451859 @default.
• W2043938659 cites W2048553024 @default.
• W2043938659 cites W2066966820 @default.
• W2043938659 cites W2072988114 @default.
• W2043938659 cites W2088895456 @default.
• W2043938659 cites W2096065464 @default.
• W2043938659 cites W2118272259 @default.
• W2043938659 cites W2153172997 @default.
• W2043938659 cites W2155208683 @default.
• W2043938659 cites W2166087647 @default.
• W2043938659 cites W2321603164 @default.
• W2043938659 cites W2332035638 @default.
• W2043938659 doi "https://doi.org/10.1016/j.bmcl.2013.03.048" @default.
• W2043938659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3677216" @default.
• W2043938659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23578690" @default.
• W2043938659 hasPublicationYear "2013" @default.
• W2043938659 type Work @default.
• W2043938659 sameAs 2043938659 @default.
• W2043938659 citedByCount "13" @default.
• W2043938659 countsByYear W20439386592014 @default.
• W2043938659 countsByYear W20439386592015 @default.
• W2043938659 countsByYear W20439386592016 @default.
• W2043938659 countsByYear W20439386592017 @default.
• W2043938659 countsByYear W20439386592019 @default.
• W2043938659 crossrefType "journal-article" @default.
• W2043938659 hasAuthorship W2043938659A5000842818 @default.
• W2043938659 hasAuthorship W2043938659A5006022002 @default.
• W2043938659 hasAuthorship W2043938659A5016359984 @default.
• W2043938659 hasAuthorship W2043938659A5019734419 @default.
• W2043938659 hasAuthorship W2043938659A5066624254 @default.
• W2043938659 hasAuthorship W2043938659A5076088772 @default.
• W2043938659 hasAuthorship W2043938659A5089946751 @default.
• W2043938659 hasBestOaLocation W20439386592 @default.
• W2043938659 hasConcept C10205521 @default.
• W2043938659 hasConcept C109316439 @default.
• W2043938659 hasConcept C131779359 @default.
• W2043938659 hasConcept C178790620 @default.
• W2043938659 hasConcept C185592680 @default.
• W2043938659 hasConcept C201750760 @default.
• W2043938659 hasConcept C202751555 @default.
• W2043938659 hasConcept C203014093 @default.
• W2043938659 hasConcept C2778041864 @default.
• W2043938659 hasConcept C2778461978 @default.
• W2043938659 hasConcept C2778729363 @default.
• W2043938659 hasConcept C28328180 @default.
• W2043938659 hasConcept C502942594 @default.
• W2043938659 hasConcept C54355233 @default.
• W2043938659 hasConcept C55493867 @default.
• W2043938659 hasConcept C57992300 @default.
• W2043938659 hasConcept C71924100 @default.
• W2043938659 hasConcept C81885089 @default.
• W2043938659 hasConcept C86803240 @default.
• W2043938659 hasConcept C95444343 @default.
• W2043938659 hasConcept C98274493 @default.
• W2043938659 hasConceptScore W2043938659C10205521 @default.
• W2043938659 hasConceptScore W2043938659C109316439 @default.
• W2043938659 hasConceptScore W2043938659C131779359 @default.
• W2043938659 hasConceptScore W2043938659C178790620 @default.
• W2043938659 hasConceptScore W2043938659C185592680 @default.
• W2043938659 hasConceptScore W2043938659C201750760 @default.
• W2043938659 hasConceptScore W2043938659C202751555 @default.
• W2043938659 hasConceptScore W2043938659C203014093 @default.
• W2043938659 hasConceptScore W2043938659C2778041864 @default.
• W2043938659 hasConceptScore W2043938659C2778461978 @default.
• W2043938659 hasConceptScore W2043938659C2778729363 @default.
• W2043938659 hasConceptScore W2043938659C28328180 @default.
• W2043938659 hasConceptScore W2043938659C502942594 @default.
• W2043938659 hasConceptScore W2043938659C54355233 @default.
• W2043938659 hasConceptScore W2043938659C55493867 @default.
• W2043938659 hasConceptScore W2043938659C57992300 @default.
• W2043938659 hasConceptScore W2043938659C71924100 @default.
• W2043938659 hasConceptScore W2043938659C81885089 @default.

• next