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- W2043941623 abstract "A resolution method has been elaborated for mandelic acid and 2-chloromandelic acid applying the (R)-(−)-3-(aminomethyl)-5-methylhexanoic acid (Pregabalin) as the resolving agent. The formation of the corresponding diastereomers was kinetically controlled. This observation was rationalized by the behavior of enantiomeric mixtures of mandelic acid, 2-chloromandelic acid, and 3-(aminomethyl)-5-methylhexanoic acid. It was found that the eutectic composition of Pregabalin influenced the diastereomeric excess of the diastereomers formed under kinetic control." @default.
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- W2043941623 date "2014-08-01" @default.
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- W2043941623 title "The effect of SDE on the separation of diastereomeric salts: a case study for the resolution of mandelic acid derivatives with Pregabalin" @default.
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- W2043941623 doi "https://doi.org/10.1016/j.tetasy.2014.06.015" @default.
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