FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043943598> ?p ?o ?g. }

• W2043943598 endingPage "78" @default.
• W2043943598 startingPage "72" @default.
• W2043943598 abstract "Although topical 1,25-dihydroxyvitamin D3 (calcitriol, 1, 25(OH)2D3) and its analogues, calcipotriol and tacalcitol, are effective for patients with psoriasis, some patients show little or no response. There is a need to develop more potent analogues of 1, 25(OH)2D3. Hexafluoro-1,25(OH)2D3 (F6-1,25(OH)2D3) is at least 10 times more potent than 1,25(OH)2D3 on calcium metabolism.We were interested in whether F6-1,25(OH)2D3 was also more potent than 1,25(OH)2D3 in inhibiting normal human and psoriatic keratinocyte proliferation.The antiproliferative activity of F6-1,25(OH)2D3 and 1,25(OH)2D3 was determined by 3H-thymidine incorporation into keratinocyte DNA and by counting basal cells.F6-1,25(OH)2D3 was approximately 10-fold more active and had a longer lasting antiproliferative effect than 1,25(OH)2D3 on normal human keratinocytes, and was about 100-fold more potent than 1, 25(OH)2D3 on human psoriatic keratinocytes as determined by 3H-thymidine incorporation. F6-1,25(OH)2D3 also caused a dose-dependent decrease in the number of basal cells and was 100-fold more active than 1,25(OH)2D3.The increased potency and the long-lasting effects of F6-1,25(OH)2D3 suggest that F6-1,25(OH)2D3 may be a potent candidate agent for treating psoriasis." @default.
• W2043943598 created "2016-06-24" @default.
• W2043943598 creator A5000267802 @default.
• W2043943598 creator A5046775144 @default.
• W2043943598 date "2000-07-01" @default.
• W2043943598 modified "2023-09-23" @default.
• W2043943598 title "Hexafluoro-1,25-dihydroxyvitamin D₃has markedly increased potency in inhibiting proliferation of cultured human keratinocytes compared with 1,25-dihydroxyvitamin D₃" @default.
• W2043943598 cites W1603740742 @default.
• W2043943598 cites W1974391793 @default.
• W2043943598 cites W1990629065 @default.
• W2043943598 cites W1996572911 @default.
• W2043943598 cites W1997429630 @default.
• W2043943598 cites W2003575314 @default.
• W2043943598 cites W2024357543 @default.
• W2043943598 cites W2030627408 @default.
• W2043943598 cites W2035325833 @default.
• W2043943598 cites W2046702183 @default.
• W2043943598 cites W2048146915 @default.
• W2043943598 cites W2049043712 @default.
• W2043943598 cites W2052518127 @default.
• W2043943598 cites W2056503051 @default.
• W2043943598 cites W2058072711 @default.
• W2043943598 cites W2060962596 @default.
• W2043943598 cites W2069861569 @default.
• W2043943598 cites W2075431280 @default.
• W2043943598 cites W2083717612 @default.
• W2043943598 cites W2086591488 @default.
• W2043943598 cites W2091985658 @default.
• W2043943598 cites W2108426329 @default.
• W2043943598 cites W2143458310 @default.
• W2043943598 cites W2155557639 @default.
• W2043943598 cites W2167132436 @default.
• W2043943598 cites W2167999248 @default.
• W2043943598 cites W2412399170 @default.
• W2043943598 cites W4245169160 @default.
• W2043943598 doi "https://doi.org/10.1046/j.1365-2133.2000.03593.x" @default.
• W2043943598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10886138" @default.
• W2043943598 hasPublicationYear "2000" @default.
• W2043943598 type Work @default.
• W2043943598 sameAs 2043943598 @default.
• W2043943598 citedByCount "12" @default.
• W2043943598 countsByYear W20439435982017 @default.
• W2043943598 crossrefType "journal-article" @default.
• W2043943598 hasAuthorship W2043943598A5000267802 @default.
• W2043943598 hasAuthorship W2043943598A5046775144 @default.
• W2043943598 hasConcept C124490489 @default.
• W2043943598 hasConcept C126322002 @default.
• W2043943598 hasConcept C134018914 @default.
• W2043943598 hasConcept C185592680 @default.
• W2043943598 hasConcept C202751555 @default.
• W2043943598 hasConcept C203014093 @default.
• W2043943598 hasConcept C2776009542 @default.
• W2043943598 hasConcept C2776079296 @default.
• W2043943598 hasConcept C2777074287 @default.
• W2043943598 hasConcept C2777108182 @default.
• W2043943598 hasConcept C2778024521 @default.
• W2043943598 hasConcept C2779306644 @default.
• W2043943598 hasConcept C2780564577 @default.
• W2043943598 hasConcept C55493867 @default.
• W2043943598 hasConcept C57992300 @default.
• W2043943598 hasConcept C64241487 @default.
• W2043943598 hasConcept C71240020 @default.
• W2043943598 hasConcept C71924100 @default.
• W2043943598 hasConcept C86803240 @default.
• W2043943598 hasConcept C98274493 @default.
• W2043943598 hasConceptScore W2043943598C124490489 @default.
• W2043943598 hasConceptScore W2043943598C126322002 @default.
• W2043943598 hasConceptScore W2043943598C134018914 @default.
• W2043943598 hasConceptScore W2043943598C185592680 @default.
• W2043943598 hasConceptScore W2043943598C202751555 @default.
• W2043943598 hasConceptScore W2043943598C203014093 @default.
• W2043943598 hasConceptScore W2043943598C2776009542 @default.
• W2043943598 hasConceptScore W2043943598C2776079296 @default.
• W2043943598 hasConceptScore W2043943598C2777074287 @default.
• W2043943598 hasConceptScore W2043943598C2777108182 @default.
• W2043943598 hasConceptScore W2043943598C2778024521 @default.
• W2043943598 hasConceptScore W2043943598C2779306644 @default.
• W2043943598 hasConceptScore W2043943598C2780564577 @default.
• W2043943598 hasConceptScore W2043943598C55493867 @default.
• W2043943598 hasConceptScore W2043943598C57992300 @default.
• W2043943598 hasConceptScore W2043943598C64241487 @default.
• W2043943598 hasConceptScore W2043943598C71240020 @default.
• W2043943598 hasConceptScore W2043943598C71924100 @default.
• W2043943598 hasConceptScore W2043943598C86803240 @default.
• W2043943598 hasConceptScore W2043943598C98274493 @default.
• W2043943598 hasIssue "1" @default.
• W2043943598 hasLocation W20439435981 @default.
• W2043943598 hasLocation W20439435982 @default.
• W2043943598 hasOpenAccess W2043943598 @default.
• W2043943598 hasPrimaryLocation W20439435981 @default.
• W2043943598 hasRelatedWork W1506296246 @default.
• W2043943598 hasRelatedWork W1996709643 @default.
• W2043943598 hasRelatedWork W2006433360 @default.
• W2043943598 hasRelatedWork W2008522868 @default.
• W2043943598 hasRelatedWork W2009717243 @default.
• W2043943598 hasRelatedWork W2015536820 @default.
• W2043943598 hasRelatedWork W2043943598 @default.
• W2043943598 hasRelatedWork W2049310692 @default.

• next