FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043945290> ?p ?o ?g. }

• W2043945290 endingPage "1521" @default.
• W2043945290 startingPage "1518" @default.
• W2043945290 abstract "Plants produce a wide variety of cyclic triterpenes, such as sterols and triterpenoids, which are the major products of the mevalonate (MVA) pathway. It is important to understand the physiological functions of HMG-CoA reductase (HMGR) because HMGR is the rate-limiting enzyme in the MVA pathway. We have previously isolated Arabidopsis mutants in HMG1 and HMG2. Although the biochemical function of HMGR2 has been thought to be almost equal to that of HMGR1, based on similarities in their sequences, the phenotypes of mutants in these genes are quite different. Whereas hmg2 shows no abnormal phenotype under normal growth conditions, hmg1 shows pleiotropic phenotypes, including dwarfing, early senescence, and male sterility. We previously postulated that the 50% decrease in the sterol content of hmg1, as compared to that in the wild type, was a cause of these phenotypes,1) but comprehensive triterpene profiles of these mutants had not yet been determined. Here, we present the triterpene profiles of hmg1 and hmg2. In contrast to hmg1, hmg2 showed a sterol content 15% lower than that of the wild type. A precise triterpenoid quantification using synthesized deuterated compounds of β-amyrin (1), α-amyrin (2), and lupeol (3) showed that the levels of triterpenoids in hmg1 and hmg2 were 65% and 25% lower than in the wild type (WT), respectively. These results demonstrate that HMGR2 as well as HMGR1 is responsible for the biosynthesis of triterpenes in spite of the lack of visible phenotypes in hmg2." @default.
• W2043945290 created "2016-06-24" @default.
• W2043945290 creator A5002282550 @default.
• W2043945290 creator A5029514297 @default.
• W2043945290 creator A5076181284 @default.
• W2043945290 creator A5079850513 @default.
• W2043945290 creator A5090028573 @default.
• W2043945290 date "2007-01-01" @default.
• W2043945290 modified "2023-09-27" @default.
• W2043945290 title "Chemical Phenotypes of the hmg1 and hmg2 Mutants of Arabidopsis Demonstrate the In-planta Role of HMG-CoA Reductase in Triterpene Biosynthesis" @default.
• W2043945290 cites W1514253620 @default.
• W2043945290 cites W1567072612 @default.
• W2043945290 cites W1589265225 @default.
• W2043945290 cites W1607854320 @default.
• W2043945290 cites W1819257473 @default.
• W2043945290 cites W1993711295 @default.
• W2043945290 cites W2011654184 @default.
• W2043945290 cites W2024426942 @default.
• W2043945290 cites W2025843309 @default.
• W2043945290 cites W2036228947 @default.
• W2043945290 cites W2044062935 @default.
• W2043945290 cites W2048710714 @default.
• W2043945290 cites W2049763956 @default.
• W2043945290 cites W2061130006 @default.
• W2043945290 cites W2066194007 @default.
• W2043945290 cites W2087445905 @default.
• W2043945290 cites W2091791271 @default.
• W2043945290 cites W2094163984 @default.
• W2043945290 cites W2108229331 @default.
• W2043945290 cites W2122230066 @default.
• W2043945290 cites W2146494718 @default.
• W2043945290 cites W2147001783 @default.
• W2043945290 cites W2155535147 @default.
• W2043945290 cites W2162883028 @default.
• W2043945290 cites W2170466045 @default.
• W2043945290 cites W4211262874 @default.
• W2043945290 cites W4238553452 @default.
• W2043945290 doi "https://doi.org/10.1248/cpb.55.1518" @default.
• W2043945290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17917299" @default.
• W2043945290 hasPublicationYear "2007" @default.
• W2043945290 type Work @default.
• W2043945290 sameAs 2043945290 @default.
• W2043945290 citedByCount "60" @default.
• W2043945290 countsByYear W20439452902012 @default.
• W2043945290 countsByYear W20439452902013 @default.
• W2043945290 countsByYear W20439452902014 @default.
• W2043945290 countsByYear W20439452902015 @default.
• W2043945290 countsByYear W20439452902016 @default.
• W2043945290 countsByYear W20439452902017 @default.
• W2043945290 countsByYear W20439452902018 @default.
• W2043945290 countsByYear W20439452902019 @default.
• W2043945290 countsByYear W20439452902020 @default.
• W2043945290 countsByYear W20439452902021 @default.
• W2043945290 countsByYear W20439452902022 @default.
• W2043945290 countsByYear W20439452902023 @default.
• W2043945290 crossrefType "journal-article" @default.
• W2043945290 hasAuthorship W2043945290A5002282550 @default.
• W2043945290 hasAuthorship W2043945290A5029514297 @default.
• W2043945290 hasAuthorship W2043945290A5076181284 @default.
• W2043945290 hasAuthorship W2043945290A5079850513 @default.
• W2043945290 hasAuthorship W2043945290A5090028573 @default.
• W2043945290 hasBestOaLocation W20439452901 @default.
• W2043945290 hasConcept C104317684 @default.
• W2043945290 hasConcept C127716648 @default.
• W2043945290 hasConcept C134651460 @default.
• W2043945290 hasConcept C142724271 @default.
• W2043945290 hasConcept C143065580 @default.
• W2043945290 hasConcept C181199279 @default.
• W2043945290 hasConcept C185592680 @default.
• W2043945290 hasConcept C204787440 @default.
• W2043945290 hasConcept C207583985 @default.
• W2043945290 hasConcept C2778163477 @default.
• W2043945290 hasConcept C2778718757 @default.
• W2043945290 hasConcept C2779491563 @default.
• W2043945290 hasConcept C2779782153 @default.
• W2043945290 hasConcept C2780527577 @default.
• W2043945290 hasConcept C553450214 @default.
• W2043945290 hasConcept C55493867 @default.
• W2043945290 hasConcept C71924100 @default.
• W2043945290 hasConceptScore W2043945290C104317684 @default.
• W2043945290 hasConceptScore W2043945290C127716648 @default.
• W2043945290 hasConceptScore W2043945290C134651460 @default.
• W2043945290 hasConceptScore W2043945290C142724271 @default.
• W2043945290 hasConceptScore W2043945290C143065580 @default.
• W2043945290 hasConceptScore W2043945290C181199279 @default.
• W2043945290 hasConceptScore W2043945290C185592680 @default.
• W2043945290 hasConceptScore W2043945290C204787440 @default.
• W2043945290 hasConceptScore W2043945290C207583985 @default.
• W2043945290 hasConceptScore W2043945290C2778163477 @default.
• W2043945290 hasConceptScore W2043945290C2778718757 @default.
• W2043945290 hasConceptScore W2043945290C2779491563 @default.
• W2043945290 hasConceptScore W2043945290C2779782153 @default.
• W2043945290 hasConceptScore W2043945290C2780527577 @default.
• W2043945290 hasConceptScore W2043945290C553450214 @default.
• W2043945290 hasConceptScore W2043945290C55493867 @default.
• W2043945290 hasConceptScore W2043945290C71924100 @default.
• W2043945290 hasIssue "10" @default.
• W2043945290 hasLocation W20439452901 @default.

• next