FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043946672> ?p ?o ?g. }

• W2043946672 endingPage "e1001101" @default.
• W2043946672 startingPage "e1001101" @default.
• W2043946672 abstract "MicroRNAs are endogenous non-coding RNAs which negatively regulate the expression of protein-coding genes in plants and animals. They are known to play an important role in several biological processes and, together with transcription factors, form a complex and highly interconnected regulatory network. Looking at the structure of this network, it is possible to recognize a few overrepresented motifs which are expected to perform important elementary regulatory functions. Among them, a special role is played by the microRNA-mediated feedforward loop in which a master transcription factor regulates a microRNA and, together with it, a set of target genes. In this paper we show analytically and through simulations that the incoherent version of this motif can couple the fine-tuning of a target protein level with an efficient noise control, thus conferring precision and stability to the overall gene expression program, especially in the presence of fluctuations in upstream regulators. Among the other results, a nontrivial prediction of our model is that the optimal attenuation of fluctuations coincides with a modest repression of the target expression. This feature is coherent with the expected fine-tuning function and in agreement with experimental observations of the actual impact of a wide class of microRNAs on the protein output of their targets. Finally, we describe the impact on noise-buffering efficiency of the cross-talk between microRNA targets that can naturally arise if the microRNA-mediated circuit is not considered as isolated, but embedded in a larger network of regulations." @default.
• W2043946672 created "2016-06-24" @default.
• W2043946672 creator A5031508753 @default.
• W2043946672 creator A5032497784 @default.
• W2043946672 creator A5063962222 @default.
• W2043946672 creator A5069341441 @default.
• W2043946672 date "2011-03-10" @default.
• W2043946672 modified "2023-10-06" @default.
• W2043946672 title "The Role of Incoherent MicroRNA-Mediated Feedforward Loops in Noise Buffering" @default.
• W2043946672 cites W144423133 @default.
• W2043946672 cites W1590222219 @default.
• W2043946672 cites W1599969036 @default.
• W2043946672 cites W1648301895 @default.
• W2043946672 cites W1963811831 @default.
• W2043946672 cites W1964261044 @default.
• W2043946672 cites W1976535231 @default.
• W2043946672 cites W1980389572 @default.
• W2043946672 cites W1983832181 @default.
• W2043946672 cites W1988163167 @default.
• W2043946672 cites W1991425207 @default.
• W2043946672 cites W1999942858 @default.
• W2043946672 cites W2009980816 @default.
• W2043946672 cites W2014946489 @default.
• W2043946672 cites W2015858554 @default.
• W2043946672 cites W2016112105 @default.
• W2043946672 cites W2017270642 @default.
• W2043946672 cites W2017718158 @default.
• W2043946672 cites W2018435536 @default.
• W2043946672 cites W2022891974 @default.
• W2043946672 cites W2032231424 @default.
• W2043946672 cites W2034500416 @default.
• W2043946672 cites W2034517352 @default.
• W2043946672 cites W2040851473 @default.
• W2043946672 cites W2042321087 @default.
• W2043946672 cites W2065566217 @default.
• W2043946672 cites W2067156314 @default.
• W2043946672 cites W2077336113 @default.
• W2043946672 cites W2080551186 @default.
• W2043946672 cites W2091198609 @default.
• W2043946672 cites W2096705138 @default.
• W2043946672 cites W2097110590 @default.
• W2043946672 cites W2097842145 @default.
• W2043946672 cites W2098044274 @default.
• W2043946672 cites W2105788966 @default.
• W2043946672 cites W2107342968 @default.
• W2043946672 cites W2111510713 @default.
• W2043946672 cites W2114870653 @default.
• W2043946672 cites W2122121413 @default.
• W2043946672 cites W2137088684 @default.
• W2043946672 cites W2137727595 @default.
• W2043946672 cites W2142688660 @default.
• W2043946672 cites W2146518187 @default.
• W2043946672 cites W2152223517 @default.
• W2043946672 cites W2153265394 @default.
• W2043946672 cites W2158469604 @default.
• W2043946672 cites W2159579373 @default.
• W2043946672 cites W2159767268 @default.
• W2043946672 cites W2160226189 @default.
• W2043946672 cites W2161977175 @default.
• W2043946672 cites W2162674813 @default.
• W2043946672 cites W2177489649 @default.
• W2043946672 cites W2910065277 @default.
• W2043946672 cites W3104970623 @default.
• W2043946672 cites W4237011200 @default.
• W2043946672 doi "https://doi.org/10.1371/journal.pcbi.1001101" @default.
• W2043946672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3053320" @default.
• W2043946672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21423718" @default.
• W2043946672 hasPublicationYear "2011" @default.
• W2043946672 type Work @default.
• W2043946672 sameAs 2043946672 @default.
• W2043946672 citedByCount "229" @default.
• W2043946672 countsByYear W20439466722012 @default.
• W2043946672 countsByYear W20439466722013 @default.
• W2043946672 countsByYear W20439466722014 @default.
• W2043946672 countsByYear W20439466722015 @default.
• W2043946672 countsByYear W20439466722016 @default.
• W2043946672 countsByYear W20439466722017 @default.
• W2043946672 countsByYear W20439466722018 @default.
• W2043946672 countsByYear W20439466722019 @default.
• W2043946672 countsByYear W20439466722020 @default.
• W2043946672 countsByYear W20439466722021 @default.
• W2043946672 countsByYear W20439466722022 @default.
• W2043946672 countsByYear W20439466722023 @default.
• W2043946672 crossrefType "journal-article" @default.
• W2043946672 hasAuthorship W2043946672A5031508753 @default.
• W2043946672 hasAuthorship W2043946672A5032497784 @default.
• W2043946672 hasAuthorship W2043946672A5063962222 @default.
• W2043946672 hasAuthorship W2043946672A5069341441 @default.
• W2043946672 hasBestOaLocation W20439466721 @default.
• W2043946672 hasConcept C104317684 @default.
• W2043946672 hasConcept C105795698 @default.
• W2043946672 hasConcept C114614502 @default.
• W2043946672 hasConcept C119056186 @default.
• W2043946672 hasConcept C121332964 @default.
• W2043946672 hasConcept C127413603 @default.
• W2043946672 hasConcept C133731056 @default.
• W2043946672 hasConcept C145059251 @default.
• W2043946672 hasConcept C150194340 @default.

• next