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- W2043947526 abstract "This study aimed to evaluate the association of genetic variants inACTN3 and MYO1H with craniofacial skeletal patterns in Brazilians.This cross-sectional study enrolled orthodontic and orthognathic patients selected from 4 regions of Brazil. Lateral cephalograms were used and digital cephalometric tracings and analyzes were performed for craniofacial phenotype determination. Participants were classified according to the skeletal malocclusion in Class I, II or III; and according to the facial type in Mesofacial, Dolichofacial or Brachyfacial. Genomic DNA was extracted from saliva samples containing exfoliated buccal epithelial cells and analyzed for genetic variants inACTN3 (rs678397 and rs1815739) and MYO1H (rs10850110) by real-time PCR. Chi-square or Fisher’s exact tests were used for statistical analysis (α = 5%).A total of 646 patients were included in the present study. There was statistically significant association of the genotypes and/or alleles distributions with the skeletal malocclusion (sagittal skeletal pattern) and facial type (vertical pattern) for the variants assessed inACTN3 (P < 0.05). For the genetic variant evaluated in MYO1H, there was statistically significant difference between the genotypes frequencies for skeletal Class I and Class II (P < 0.05). The reported associations were different depending on the region evaluated.ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns in Brazilian populations." @default.
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- W2043947526 date "1997-01-01" @default.
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- W2043947526 title "1047 Formation of the retinorecipient layers in relation to the terminal arborization of retinotectal fibers in the chick optic tectum" @default.
- W2043947526 doi "https://doi.org/10.1016/s0168-0102(97)90351-5" @default.
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