Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043948229> ?p ?o ?g. }
- W2043948229 endingPage "810" @default.
- W2043948229 startingPage "801" @default.
- W2043948229 abstract "Nucleic acid-binding innate immune receptors such as Toll-like receptor 7 (TLR7) and TLR9 have been implicated in the development of some autoimmune pathologies. The Y chromosome-linked genomic modifier Yaa, which correlates with a duplication of Tlr7 and 16 other genes, exacerbates lupus-like syndromes in several mouse strains. Here we demonstrated that duplication of the Tlr7 gene was the sole requirement for this accelerated autoimmunity, because reduction of Tlr7 gene dosage abolished the Yaa phenotype. Further, we described new transgenic lines that overexpressed TLR7 alone and found that spontaneous autoimmunity developed beyond a 2-fold increase in TLR7 expression. Whereas a modest increase in Tlr7 gene dosage promoted autoreactive lymphocytes with RNA specificities and myeloid cell proliferation, a substantial increase in TLR7 expression caused fatal acute inflammatory pathology and profound dendritic cell dysregulation. These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses." @default.
- W2043948229 created "2016-06-24" @default.
- W2043948229 creator A5013212463 @default.
- W2043948229 creator A5016366290 @default.
- W2043948229 creator A5016713616 @default.
- W2043948229 creator A5057629293 @default.
- W2043948229 creator A5061909361 @default.
- W2043948229 creator A5064443404 @default.
- W2043948229 creator A5068060329 @default.
- W2043948229 creator A5071714593 @default.
- W2043948229 date "2007-11-01" @default.
- W2043948229 modified "2023-10-15" @default.
- W2043948229 title "Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation" @default.
- W2043948229 cites W1666780611 @default.
- W2043948229 cites W1860362201 @default.
- W2043948229 cites W1919093559 @default.
- W2043948229 cites W1975069660 @default.
- W2043948229 cites W1983940041 @default.
- W2043948229 cites W1995928270 @default.
- W2043948229 cites W2001988677 @default.
- W2043948229 cites W2014035331 @default.
- W2043948229 cites W2025412364 @default.
- W2043948229 cites W2028111124 @default.
- W2043948229 cites W2031355052 @default.
- W2043948229 cites W2034708798 @default.
- W2043948229 cites W2040459416 @default.
- W2043948229 cites W2042797177 @default.
- W2043948229 cites W2047366876 @default.
- W2043948229 cites W2051177901 @default.
- W2043948229 cites W2052521175 @default.
- W2043948229 cites W2060776279 @default.
- W2043948229 cites W2068975016 @default.
- W2043948229 cites W2072613935 @default.
- W2043948229 cites W2100706488 @default.
- W2043948229 cites W2105901907 @default.
- W2043948229 cites W2109191041 @default.
- W2043948229 cites W2109231206 @default.
- W2043948229 cites W2119293746 @default.
- W2043948229 cites W2129708174 @default.
- W2043948229 cites W2134106169 @default.
- W2043948229 cites W2136752250 @default.
- W2043948229 cites W2144081036 @default.
- W2043948229 cites W2156418336 @default.
- W2043948229 cites W2157721335 @default.
- W2043948229 cites W2157847612 @default.
- W2043948229 cites W2161093494 @default.
- W2043948229 cites W2161208630 @default.
- W2043948229 cites W2164865997 @default.
- W2043948229 cites W2165591553 @default.
- W2043948229 cites W2166626628 @default.
- W2043948229 cites W2167797671 @default.
- W2043948229 cites W2842267605 @default.
- W2043948229 cites W35413080 @default.
- W2043948229 cites W4249383371 @default.
- W2043948229 doi "https://doi.org/10.1016/j.immuni.2007.09.009" @default.
- W2043948229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2706502" @default.
- W2043948229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997333" @default.
- W2043948229 hasPublicationYear "2007" @default.
- W2043948229 type Work @default.
- W2043948229 sameAs 2043948229 @default.
- W2043948229 citedByCount "475" @default.
- W2043948229 countsByYear W20439482292012 @default.
- W2043948229 countsByYear W20439482292013 @default.
- W2043948229 countsByYear W20439482292014 @default.
- W2043948229 countsByYear W20439482292015 @default.
- W2043948229 countsByYear W20439482292016 @default.
- W2043948229 countsByYear W20439482292017 @default.
- W2043948229 countsByYear W20439482292018 @default.
- W2043948229 countsByYear W20439482292019 @default.
- W2043948229 countsByYear W20439482292020 @default.
- W2043948229 countsByYear W20439482292021 @default.
- W2043948229 countsByYear W20439482292022 @default.
- W2043948229 countsByYear W20439482292023 @default.
- W2043948229 crossrefType "journal-article" @default.
- W2043948229 hasAuthorship W2043948229A5013212463 @default.
- W2043948229 hasAuthorship W2043948229A5016366290 @default.
- W2043948229 hasAuthorship W2043948229A5016713616 @default.
- W2043948229 hasAuthorship W2043948229A5057629293 @default.
- W2043948229 hasAuthorship W2043948229A5061909361 @default.
- W2043948229 hasAuthorship W2043948229A5064443404 @default.
- W2043948229 hasAuthorship W2043948229A5068060329 @default.
- W2043948229 hasAuthorship W2043948229A5071714593 @default.
- W2043948229 hasBestOaLocation W20439482291 @default.
- W2043948229 hasConcept C104317684 @default.
- W2043948229 hasConcept C136449434 @default.
- W2043948229 hasConcept C150194340 @default.
- W2043948229 hasConcept C190727270 @default.
- W2043948229 hasConcept C203014093 @default.
- W2043948229 hasConcept C2776709828 @default.
- W2043948229 hasConcept C2779138994 @default.
- W2043948229 hasConcept C2779836521 @default.
- W2043948229 hasConcept C2780130043 @default.
- W2043948229 hasConcept C54355233 @default.
- W2043948229 hasConcept C86803240 @default.
- W2043948229 hasConcept C8891405 @default.
- W2043948229 hasConcept C95444343 @default.
- W2043948229 hasConceptScore W2043948229C104317684 @default.
- W2043948229 hasConceptScore W2043948229C136449434 @default.