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• W2043951259 startingPage "123" @default.
• W2043951259 abstract "Ribozymes use a number of the same catalytic strategies as protein enzymes. However, general base catalysis by a ribozyme has not been demonstrated. In the hepatitis delta virus antigenomic ribozyme, imidazole buffer rescued activity of a mutant with a cytosine-76 (C76) to uracil substitution. In addition, a C76 to adenine substitution reduced the apparent pKa (where Ka is the acid constant) of the self-cleavage reaction by an amount consistent with differences in the pKa values of these two side chains. These results suggest that, in the wild-type ribozyme, C76 acts as a general base. This finding has implications for potential catalytic functions of conserved cytosines and adenines in other ribozymes and in ribonuclear proteins with enzymatic activity." @default.
• W2043951259 created "2016-06-24" @default.
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• W2043951259 date "1999-10-01" @default.
• W2043951259 modified "2023-10-10" @default.
• W2043951259 title "Imidazole Rescue of a Cytosine Mutation in a Self-Cleaving Ribozyme" @default.
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• W2043951259 doi "https://doi.org/10.1126/science.286.5437.123" @default.
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