Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043955672> ?p ?o ?g. }
- W2043955672 endingPage "1263" @default.
- W2043955672 startingPage "1256" @default.
- W2043955672 abstract "Abstract Matrix metalloproteinases (MMPs) belong to a family of zinc dependent enzymes best studied for their role in cancer and inflammation. Though MMPs typically target extracellular proteins, here we show that MMP‐7, an MMP family member which lacks a C‐terminal hemopexin‐like domain, can cleave an intraneuronal protein that is critical to vesicular fusion and neurotransmitter release, synaptosomal‐associated protein of 25 kDa (SNAP‐25). Western blot analysis using an N‐terminal specific antibody on extracts from cultured neurons suggests that cleavage occurs towards the C‐terminal portion of SNAP 25. Additional studies with recombinant SNAP‐25 demonstrate that cleavage occurs at amino acid 129. The ability of MMP‐7 to cleave SNAP‐25 is diminished by chlorpromazine and phenylarsine oxide, inhibitors of clathrin dependent endocytosis. Together, these results imply that exogenous MMP‐7 can access an intraneuronal substrate and suggest that additional studies may be warranted to determine if SNAP function is impaired with brain inflammation." @default.
- W2043955672 created "2016-06-24" @default.
- W2043955672 creator A5016574445 @default.
- W2043955672 creator A5034805147 @default.
- W2043955672 creator A5044283681 @default.
- W2043955672 creator A5056628350 @default.
- W2043955672 creator A5082745849 @default.
- W2043955672 date "2007-04-10" @default.
- W2043955672 modified "2023-09-30" @default.
- W2043955672 title "Cleavage of neuronal synaptosomal-associated protein of 25 kDa by exogenous matrix metalloproteinase-7" @default.
- W2043955672 cites W112299954 @default.
- W2043955672 cites W1524110814 @default.
- W2043955672 cites W1569488450 @default.
- W2043955672 cites W1619234695 @default.
- W2043955672 cites W1659429211 @default.
- W2043955672 cites W1955736456 @default.
- W2043955672 cites W1968072037 @default.
- W2043955672 cites W1969381238 @default.
- W2043955672 cites W1977183609 @default.
- W2043955672 cites W1983957620 @default.
- W2043955672 cites W1988129426 @default.
- W2043955672 cites W1991625690 @default.
- W2043955672 cites W1992431969 @default.
- W2043955672 cites W1994465396 @default.
- W2043955672 cites W1999213641 @default.
- W2043955672 cites W2002468770 @default.
- W2043955672 cites W2004656949 @default.
- W2043955672 cites W2013377378 @default.
- W2043955672 cites W2022070280 @default.
- W2043955672 cites W2029325168 @default.
- W2043955672 cites W2030054084 @default.
- W2043955672 cites W2030104330 @default.
- W2043955672 cites W2032743208 @default.
- W2043955672 cites W2033449185 @default.
- W2043955672 cites W2043377800 @default.
- W2043955672 cites W2043999088 @default.
- W2043955672 cites W2056006269 @default.
- W2043955672 cites W2062193828 @default.
- W2043955672 cites W2069500280 @default.
- W2043955672 cites W2073793348 @default.
- W2043955672 cites W2077034347 @default.
- W2043955672 cites W2079241115 @default.
- W2043955672 cites W2080984034 @default.
- W2043955672 cites W2085680244 @default.
- W2043955672 cites W2086696756 @default.
- W2043955672 cites W2088270109 @default.
- W2043955672 cites W2089974427 @default.
- W2043955672 cites W2091284200 @default.
- W2043955672 cites W2093603576 @default.
- W2043955672 cites W2099969611 @default.
- W2043955672 cites W2105887776 @default.
- W2043955672 cites W2111476808 @default.
- W2043955672 cites W2117308838 @default.
- W2043955672 cites W2121908124 @default.
- W2043955672 cites W2123832957 @default.
- W2043955672 cites W2128049766 @default.
- W2043955672 cites W2128685320 @default.
- W2043955672 cites W2140552779 @default.
- W2043955672 cites W2153763976 @default.
- W2043955672 cites W2154100802 @default.
- W2043955672 cites W2154401382 @default.
- W2043955672 cites W2154678377 @default.
- W2043955672 cites W2157512308 @default.
- W2043955672 cites W2158858936 @default.
- W2043955672 cites W2159141617 @default.
- W2043955672 cites W2159672669 @default.
- W2043955672 cites W2162639406 @default.
- W2043955672 cites W2171288469 @default.
- W2043955672 cites W2773388190 @default.
- W2043955672 cites W4239566557 @default.
- W2043955672 doi "https://doi.org/10.1111/j.1471-4159.2007.04625.x" @default.
- W2043955672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17472697" @default.
- W2043955672 hasPublicationYear "2007" @default.
- W2043955672 type Work @default.
- W2043955672 sameAs 2043955672 @default.
- W2043955672 citedByCount "25" @default.
- W2043955672 countsByYear W20439556722012 @default.
- W2043955672 countsByYear W20439556722013 @default.
- W2043955672 countsByYear W20439556722015 @default.
- W2043955672 countsByYear W20439556722016 @default.
- W2043955672 countsByYear W20439556722017 @default.
- W2043955672 countsByYear W20439556722018 @default.
- W2043955672 countsByYear W20439556722019 @default.
- W2043955672 countsByYear W20439556722021 @default.
- W2043955672 countsByYear W20439556722022 @default.
- W2043955672 countsByYear W20439556722023 @default.
- W2043955672 crossrefType "journal-article" @default.
- W2043955672 hasAuthorship W2043955672A5016574445 @default.
- W2043955672 hasAuthorship W2043955672A5034805147 @default.
- W2043955672 hasAuthorship W2043955672A5044283681 @default.
- W2043955672 hasAuthorship W2043955672A5056628350 @default.
- W2043955672 hasAuthorship W2043955672A5082745849 @default.
- W2043955672 hasConcept C104317684 @default.
- W2043955672 hasConcept C109523444 @default.
- W2043955672 hasConcept C151730666 @default.
- W2043955672 hasConcept C170493617 @default.
- W2043955672 hasConcept C175156509 @default.
- W2043955672 hasConcept C175969161 @default.