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- W2043955803 abstract "The purpose of this study was to determine the effects of a long-term infusion into the fetal circulaton on fetal and amniotic fluid dynamics. In 10 chronically catheterized fetal sheep averaging 130 ± 1 (SE) days' gestation, a balanced, isotonic electrolyte solution (Isolyte S) was infused continuously for 5 days into a fetal vein at a rate of 0, 1, 2, 4, and 0 L/day, respectively. During the infusion, fetal blood volume increased by a maximum of 6.4 ± 2.0% (p < 0.001 ), and the daily swallowing of amniotic fluid doubled (p < 0.001 ). Fetal urine flow increased (p < 0.0001) above preinfusion rates by a volume equal to the infusion rate plus the increase in swallowing, whereas renal excretion of sodium and chloride increased by the amount infused. The increase in the plasma concentration of atrial natriuretic factor (p < 0.0001) and the decrease in arginine vasopression (p < 0.05) were not linearly related to urine flow changes. Amniotic fluid volume increased (p < 0.0001) by 20% of the infused volume. All values returned to normal on day 5 except amniotic fluid volume, which remained elevated. Estimated allantoic fluid volume at the end of day 5 was 800 ml above normal. Thus it appears that on a long-term basis, the ovine fetus eliminates infused water and electrolytes through its kidneys rather than across the placenta. Although all of the infused volume left the fetus through its kidneys, only 30% of the infused volume remained in the amniotic and allantoic fluid compartments, suggesting transfer to the mother by unknown mechanisms." @default.
- W2043955803 created "2016-06-24" @default.
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- W2043955803 date "1989-10-01" @default.
- W2043955803 modified "2023-09-27" @default.
- W2043955803 title "Fetal blood volume, urine flow, swallowing, and amniotic fluid volume responses to long-term intravascular infusions of saline" @default.
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- W2043955803 doi "https://doi.org/10.1016/0002-9378(89)90782-5" @default.
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