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• W2043955819 abstract "Type-D or distressed personality and depression following admission for acute coronary syndrome (ACS) have been associated with poor clinical outcome. The biological pathways underpinning this relationship may include disruption of the hypothalamic-pituitary-adrenocortical (HPA) axis. We therefore assessed cortisol output in patients who had recently suffered from ACS.Salivary cortisol was assessed eight times over a 24-h period in 72 patients within 5 days of admission for ACS. Depressive symptoms were measured with the Beck Depression Inventory (BDI), and type-D personality was measured with the Type-D Scale-16. Particular attention was given to cortisol awakening response (CAR), which was measured as the difference in cortisol between waking and peak responses 15-30 min later.Cortisol showed a typical diurnal pattern, with low levels in the evening, high levels early in the day, and CAR averaging 7.58+/-10.0 nmol/l. Cortisol was not related to the severity of ACS or underlying coronary artery disease or to BDI scores. The CAR was positively associated with type-D personality independently of age, gender, and body mass (P=.007). Linear regression showed that type-D personality accounted for 7.9% of the variance in CAR after age, sex, body mass, BDI, cortisol level on waking, and fatigue had been taken into account (P=.008).Type-D personality may be associated with disruption of HPA axis function in survivors of acute cardiac events and may contribute to heightened inflammatory responses influencing future cardiac morbidity." @default.
• W2043955819 created "2016-06-24" @default.
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• W2043955819 date "2007-04-01" @default.
• W2043955819 modified "2023-09-26" @default.
• W2043955819 title "Cortisol awakening response is elevated in acute coronary syndrome patients with type-D personality" @default.
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• W2043955819 doi "https://doi.org/10.1016/j.jpsychores.2006.11.005" @default.
• W2043955819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17383493" @default.
• W2043955819 hasPublicationYear "2007" @default.
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