Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043961103> ?p ?o ?g. }
- W2043961103 endingPage "2610" @default.
- W2043961103 startingPage "2599" @default.
- W2043961103 abstract "Production of type I interferons (IFNs; prominently, IFN-α/β) following virus infection is a pivotal antiviral innate immune response in higher vertebrates. The synthesis of IFN-β proceeds via the virus-induced assembly of the transcription factors IRF-3/7, ATF-2/c-Jun, and NF-κB on the ifnβ promoter. Surprisingly, recent data indicate that the NF-κB subunit RelA is not essential for virus-stimulated ifnβ expression. Here, we show that RelA instead sustains autocrine IFN-β signaling prior to infection. In the absence of RelA, virus infection results in significantly delayed ifnβ induction and consequently defective secondary antiviral gene expression. While RelA is not required for ifnβ expression after infection, it is nonetheless essential for fully one-fourth of double-stranded RNA (dsRNA)-activated genes, including several mediators of inflammation and immune cell recruitment. Further, RelA directly regulates a small subset of interferon-stimulated genes (ISGs). Finally, RelA also protects cells from dsRNA-triggered RIP1-dependent programmed necrosis. Taken together, our findings suggest distinct roles for RelA in antiviral innate immunity: RelA maintains autocrine IFN-β signaling in uninfected cells, facilitates inflammatory and adaptive immune responses following infection, and promotes infected-cell survival during this process." @default.
- W2043961103 created "2016-06-24" @default.
- W2043961103 creator A5002934039 @default.
- W2043961103 creator A5021503101 @default.
- W2043961103 creator A5032171890 @default.
- W2043961103 creator A5032428730 @default.
- W2043961103 creator A5050588622 @default.
- W2043961103 creator A5060554995 @default.
- W2043961103 date "2011-03-15" @default.
- W2043961103 modified "2023-10-06" @default.
- W2043961103 title "Distinct Roles for the NF-κB RelA Subunit during Antiviral Innate Immune Responses" @default.
- W2043961103 cites W1488480791 @default.
- W2043961103 cites W152118174 @default.
- W2043961103 cites W1542209374 @default.
- W2043961103 cites W1553110542 @default.
- W2043961103 cites W1604852883 @default.
- W2043961103 cites W1849717039 @default.
- W2043961103 cites W1966282784 @default.
- W2043961103 cites W1973472843 @default.
- W2043961103 cites W1975764372 @default.
- W2043961103 cites W1977365050 @default.
- W2043961103 cites W1978437791 @default.
- W2043961103 cites W1979032223 @default.
- W2043961103 cites W1979582699 @default.
- W2043961103 cites W1992412371 @default.
- W2043961103 cites W1994718301 @default.
- W2043961103 cites W1995744610 @default.
- W2043961103 cites W1997767982 @default.
- W2043961103 cites W2002674047 @default.
- W2043961103 cites W2004312418 @default.
- W2043961103 cites W2008913175 @default.
- W2043961103 cites W2011678998 @default.
- W2043961103 cites W2028575270 @default.
- W2043961103 cites W2028859420 @default.
- W2043961103 cites W2038401000 @default.
- W2043961103 cites W2040653543 @default.
- W2043961103 cites W2041106589 @default.
- W2043961103 cites W2042347911 @default.
- W2043961103 cites W2048485003 @default.
- W2043961103 cites W2052605153 @default.
- W2043961103 cites W2055759015 @default.
- W2043961103 cites W2058016035 @default.
- W2043961103 cites W2058554631 @default.
- W2043961103 cites W2060204808 @default.
- W2043961103 cites W2063800096 @default.
- W2043961103 cites W2068006559 @default.
- W2043961103 cites W2068466303 @default.
- W2043961103 cites W2079045730 @default.
- W2043961103 cites W2079357798 @default.
- W2043961103 cites W2081098333 @default.
- W2043961103 cites W2089077517 @default.
- W2043961103 cites W2091554591 @default.
- W2043961103 cites W2094863064 @default.
- W2043961103 cites W2095401221 @default.
- W2043961103 cites W2095699041 @default.
- W2043961103 cites W2098269483 @default.
- W2043961103 cites W2103565638 @default.
- W2043961103 cites W2106519587 @default.
- W2043961103 cites W2111724750 @default.
- W2043961103 cites W2118430628 @default.
- W2043961103 cites W2118701021 @default.
- W2043961103 cites W2122506044 @default.
- W2043961103 cites W2125566625 @default.
- W2043961103 cites W2137077743 @default.
- W2043961103 cites W2138677670 @default.
- W2043961103 cites W2141423929 @default.
- W2043961103 cites W2148119611 @default.
- W2043961103 cites W2150701651 @default.
- W2043961103 cites W2150878299 @default.
- W2043961103 cites W2155005693 @default.
- W2043961103 cites W2158662692 @default.
- W2043961103 cites W2160697532 @default.
- W2043961103 cites W2161830466 @default.
- W2043961103 cites W2161832141 @default.
- W2043961103 cites W2170236911 @default.
- W2043961103 cites W2171167766 @default.
- W2043961103 doi "https://doi.org/10.1128/jvi.02213-10" @default.
- W2043961103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067974" @default.
- W2043961103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209118" @default.
- W2043961103 hasPublicationYear "2011" @default.
- W2043961103 type Work @default.
- W2043961103 sameAs 2043961103 @default.
- W2043961103 citedByCount "76" @default.
- W2043961103 countsByYear W20439611032012 @default.
- W2043961103 countsByYear W20439611032013 @default.
- W2043961103 countsByYear W20439611032014 @default.
- W2043961103 countsByYear W20439611032015 @default.
- W2043961103 countsByYear W20439611032016 @default.
- W2043961103 countsByYear W20439611032017 @default.
- W2043961103 countsByYear W20439611032018 @default.
- W2043961103 countsByYear W20439611032019 @default.
- W2043961103 countsByYear W20439611032020 @default.
- W2043961103 countsByYear W20439611032021 @default.
- W2043961103 countsByYear W20439611032022 @default.
- W2043961103 countsByYear W20439611032023 @default.
- W2043961103 crossrefType "journal-article" @default.
- W2043961103 hasAuthorship W2043961103A5002934039 @default.
- W2043961103 hasAuthorship W2043961103A5021503101 @default.