Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043965664> ?p ?o ?g. }
- W2043965664 endingPage "315" @default.
- W2043965664 startingPage "310" @default.
- W2043965664 abstract "Purpose of review The present review considers recent reports that identify the roles of key intermediate signaling components and mediators during and after mast cell activation and degranulation leading to anaphylaxis. Recent findings Mechanisms of anaphylaxis are becoming better understood as the interaction of several regulatory systems in the mast cell activation and degranulation signaling cascade. Multiple tyrosine kinases, activated after immunoglobulin E binding to the high-affinity receptors for immunoglobulin E (FcεRI), exert both positive and negative regulation on the signaling cascade, which may vary with genetic background or mutations in signaling proteins. Calcium influx, the essential, proximal intracellular event leading to mast cell degranulation, is controlled also by both negative and positive regulation through calcium channels. Sphingosine-1-phosphate is emerging as a newly realized mediator of anaphylaxis, acting as a signaling component within the mast cell and as a circulating mediator. Summary Anaphylaxis is a systemic reaction involving multiple organ systems, but it is believed that it may be influenced by cellular events in mast cells and basophils resulting in the release of mediators. Therefore, understanding the mechanisms of mast cell activation and degranulation is critical to understanding the mechanisms of anaphylaxis. Recent reports have identified important regulatory components of the signaling cascade and, consequently, potential targets for therapeutic intervention." @default.
- W2043965664 created "2016-06-24" @default.
- W2043965664 creator A5011039354 @default.
- W2043965664 creator A5086857854 @default.
- W2043965664 date "2008-08-01" @default.
- W2043965664 modified "2023-10-16" @default.
- W2043965664 title "Understanding the mechanisms of anaphylaxis" @default.
- W2043965664 cites W1866106776 @default.
- W2043965664 cites W1894018091 @default.
- W2043965664 cites W1971090143 @default.
- W2043965664 cites W1974829480 @default.
- W2043965664 cites W1978707192 @default.
- W2043965664 cites W1981034102 @default.
- W2043965664 cites W1985668252 @default.
- W2043965664 cites W1988124754 @default.
- W2043965664 cites W1989730805 @default.
- W2043965664 cites W1999767268 @default.
- W2043965664 cites W2003879757 @default.
- W2043965664 cites W2004148398 @default.
- W2043965664 cites W2005479212 @default.
- W2043965664 cites W2013187404 @default.
- W2043965664 cites W2015082452 @default.
- W2043965664 cites W2017434802 @default.
- W2043965664 cites W2024510824 @default.
- W2043965664 cites W2030066805 @default.
- W2043965664 cites W2031966403 @default.
- W2043965664 cites W2034820412 @default.
- W2043965664 cites W2051118426 @default.
- W2043965664 cites W2052951012 @default.
- W2043965664 cites W2057907984 @default.
- W2043965664 cites W2061452912 @default.
- W2043965664 cites W2071324084 @default.
- W2043965664 cites W2076822575 @default.
- W2043965664 cites W2080719665 @default.
- W2043965664 cites W2083185357 @default.
- W2043965664 cites W2085435814 @default.
- W2043965664 cites W2085577106 @default.
- W2043965664 cites W2092222004 @default.
- W2043965664 cites W2100529070 @default.
- W2043965664 cites W2113892275 @default.
- W2043965664 cites W2116677745 @default.
- W2043965664 cites W2119961921 @default.
- W2043965664 cites W2120959166 @default.
- W2043965664 cites W2137385183 @default.
- W2043965664 cites W2151766517 @default.
- W2043965664 cites W2154587917 @default.
- W2043965664 cites W2158722170 @default.
- W2043965664 cites W2166738676 @default.
- W2043965664 cites W2168921529 @default.
- W2043965664 cites W3188718490 @default.
- W2043965664 cites W4229620302 @default.
- W2043965664 cites W4231271238 @default.
- W2043965664 doi "https://doi.org/10.1097/aci.0b013e3283036a90" @default.
- W2043965664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683407" @default.
- W2043965664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18596587" @default.
- W2043965664 hasPublicationYear "2008" @default.
- W2043965664 type Work @default.
- W2043965664 sameAs 2043965664 @default.
- W2043965664 citedByCount "152" @default.
- W2043965664 countsByYear W20439656642012 @default.
- W2043965664 countsByYear W20439656642013 @default.
- W2043965664 countsByYear W20439656642014 @default.
- W2043965664 countsByYear W20439656642015 @default.
- W2043965664 countsByYear W20439656642016 @default.
- W2043965664 countsByYear W20439656642017 @default.
- W2043965664 countsByYear W20439656642018 @default.
- W2043965664 countsByYear W20439656642019 @default.
- W2043965664 countsByYear W20439656642020 @default.
- W2043965664 countsByYear W20439656642021 @default.
- W2043965664 countsByYear W20439656642022 @default.
- W2043965664 countsByYear W20439656642023 @default.
- W2043965664 crossrefType "journal-article" @default.
- W2043965664 hasAuthorship W2043965664A5011039354 @default.
- W2043965664 hasAuthorship W2043965664A5086857854 @default.
- W2043965664 hasBestOaLocation W20439656642 @default.
- W2043965664 hasConcept C126322002 @default.
- W2043965664 hasConcept C141105273 @default.
- W2043965664 hasConcept C159654299 @default.
- W2043965664 hasConcept C170493617 @default.
- W2043965664 hasConcept C201571599 @default.
- W2043965664 hasConcept C203014093 @default.
- W2043965664 hasConcept C207480886 @default.
- W2043965664 hasConcept C2107291 @default.
- W2043965664 hasConcept C2775933838 @default.
- W2043965664 hasConcept C2776914184 @default.
- W2043965664 hasConcept C2779726688 @default.
- W2043965664 hasConcept C49802076 @default.
- W2043965664 hasConcept C62478195 @default.
- W2043965664 hasConcept C71924100 @default.
- W2043965664 hasConcept C86803240 @default.
- W2043965664 hasConcept C95444343 @default.
- W2043965664 hasConceptScore W2043965664C126322002 @default.
- W2043965664 hasConceptScore W2043965664C141105273 @default.
- W2043965664 hasConceptScore W2043965664C159654299 @default.
- W2043965664 hasConceptScore W2043965664C170493617 @default.
- W2043965664 hasConceptScore W2043965664C201571599 @default.
- W2043965664 hasConceptScore W2043965664C203014093 @default.
- W2043965664 hasConceptScore W2043965664C207480886 @default.