FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2043970086> ?p ?o ?g. }

• W2043970086 endingPage "115" @default.
• W2043970086 startingPage "115" @default.
• W2043970086 abstract "Outcome of the HORIZONS-AMI trial: bivalirudin enhances long-term survival in patients with ST-elevation myocardial infarction undergoing angioplasty Ashish Shah, Dmitriy N FeldmanGreenberg Division of Cardiology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USAAbstract: Cardiovascular disease is the leading cause of death in the US. For patients with ST-elevation myocardial infarction (STEMI), urgent reperfusion of the culprit arterial occlusion, often achieved via primary percutaneous coronary intervention (PCI), reduces post-MI mortality and other major adverse cardiovascular events (MACE). Adjunctive antithrombotic and antiplatelet therapies are used during PCI to reduce MACE rates. Currently, a variety of antithrombotic options are available for peri-procedural use. The most commonly used agents include unfractionated heparin or low molecular weight heparin ± glycoprotein IIb/IIIa inhibitors (GPI). These agents reduce the rates of peri-procedural ischemic and thrombotic events, though these benefits come at the cost of an increase in bleeding complications. Bivalirudin is a direct thrombin inhibitor with a short half-life and linear pharmacokinetics, which results in predictable serum concentrations and anticoagulant effect. Bivalirudin has emerged as an efficacious and safe alternative to heparin plus GP IIb/IIIa inhibitors in both stable coronary artery disease and acute coronary syndrome patients. In the HORIZONS-AMI trial, monotherapy with bivalirudin was compared with the combination of heparin and a GPI in a large population of patients with STEMI who underwent primary PCI. Bivalirudin treatment was associated with improved event-free survival at 30 days and reduced rates of major bleeding. Based on the results of the trial, the American College of Cardiology/American Heart Association and European Society of Cardiology guidelines have incorporated recommendations for bivalirudin use in the setting of STEMI. Recently, 3-year follow-up data from the HORIZONS-AMI cohort were published, demonstrating sustained benefits in patients treated with bivalirudin, including reduced rates of mortality, cardiovascular mortality, reinfarction, and major bleeding events. These results further support the use of bivalirudin in the setting of primary PCI for STEMI given that its benefits are maintained through long-term follow-up.Keywords: bivalirudin, antithrombotic, ST-elevation myocardial infarction, acute coronary syndrome, PCI" @default.
• W2043970086 created "2016-06-24" @default.
• W2043970086 creator A5020439269 @default.
• W2043970086 creator A5082826312 @default.
• W2043970086 date "2012-02-01" @default.
• W2043970086 modified "2023-09-30" @default.
• W2043970086 title "Outcome of the HORIZONS-AMI trial: bivalirudin enhances long-term survival in patients with ST-elevation myocardial infarction undergoing angioplasty" @default.
• W2043970086 cites W107577559 @default.
• W2043970086 cites W148335572 @default.
• W2043970086 cites W161671725 @default.
• W2043970086 cites W176159753 @default.
• W2043970086 cites W1966920686 @default.
• W2043970086 cites W1985088220 @default.
• W2043970086 cites W1990864736 @default.
• W2043970086 cites W2013537866 @default.
• W2043970086 cites W2028470404 @default.
• W2043970086 cites W2056663716 @default.
• W2043970086 cites W2059289792 @default.
• W2043970086 cites W2061381591 @default.
• W2043970086 cites W2085413583 @default.
• W2043970086 cites W2099409915 @default.
• W2043970086 cites W2102296549 @default.
• W2043970086 cites W2103428481 @default.
• W2043970086 cites W2105988283 @default.
• W2043970086 cites W2117254307 @default.
• W2043970086 cites W2121251309 @default.
• W2043970086 cites W2122888263 @default.
• W2043970086 cites W2126893609 @default.
• W2043970086 cites W2130219973 @default.
• W2043970086 cites W2140442988 @default.
• W2043970086 cites W2148678963 @default.
• W2043970086 cites W2154783291 @default.
• W2043970086 cites W2156927593 @default.
• W2043970086 cites W2164749239 @default.
• W2043970086 cites W2329490408 @default.
• W2043970086 cites W2333133657 @default.
• W2043970086 cites W2568050971 @default.
• W2043970086 cites W2614781785 @default.
• W2043970086 cites W2616526627 @default.
• W2043970086 cites W2887768525 @default.
• W2043970086 cites W51590583 @default.
• W2043970086 doi "https://doi.org/10.2147/vhrm.s23491" @default.
• W2043970086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3295633" @default.
• W2043970086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22399856" @default.
• W2043970086 hasPublicationYear "2012" @default.
• W2043970086 type Work @default.
• W2043970086 sameAs 2043970086 @default.
• W2043970086 citedByCount "3" @default.
• W2043970086 countsByYear W20439700862015 @default.
• W2043970086 countsByYear W20439700862017 @default.
• W2043970086 countsByYear W20439700862023 @default.
• W2043970086 crossrefType "journal-article" @default.
• W2043970086 hasAuthorship W2043970086A5020439269 @default.
• W2043970086 hasAuthorship W2043970086A5082826312 @default.
• W2043970086 hasBestOaLocation W20439700861 @default.
• W2043970086 hasConcept C126322002 @default.
• W2043970086 hasConcept C164705383 @default.
• W2043970086 hasConcept C2776301958 @default.
• W2043970086 hasConcept C2776710957 @default.
• W2043970086 hasConcept C2777015399 @default.
• W2043970086 hasConcept C2777557582 @default.
• W2043970086 hasConcept C2777565915 @default.
• W2043970086 hasConcept C2777698277 @default.
• W2043970086 hasConcept C2778213512 @default.
• W2043970086 hasConcept C2778810321 @default.
• W2043970086 hasConcept C2779161974 @default.
• W2043970086 hasConcept C2780326628 @default.
• W2043970086 hasConcept C2780400711 @default.
• W2043970086 hasConcept C2780739214 @default.
• W2043970086 hasConcept C2908647359 @default.
• W2043970086 hasConcept C45393284 @default.
• W2043970086 hasConcept C500558357 @default.
• W2043970086 hasConcept C71924100 @default.
• W2043970086 hasConcept C99454951 @default.
• W2043970086 hasConceptScore W2043970086C126322002 @default.
• W2043970086 hasConceptScore W2043970086C164705383 @default.
• W2043970086 hasConceptScore W2043970086C2776301958 @default.
• W2043970086 hasConceptScore W2043970086C2776710957 @default.
• W2043970086 hasConceptScore W2043970086C2777015399 @default.
• W2043970086 hasConceptScore W2043970086C2777557582 @default.
• W2043970086 hasConceptScore W2043970086C2777565915 @default.
• W2043970086 hasConceptScore W2043970086C2777698277 @default.
• W2043970086 hasConceptScore W2043970086C2778213512 @default.
• W2043970086 hasConceptScore W2043970086C2778810321 @default.
• W2043970086 hasConceptScore W2043970086C2779161974 @default.
• W2043970086 hasConceptScore W2043970086C2780326628 @default.
• W2043970086 hasConceptScore W2043970086C2780400711 @default.
• W2043970086 hasConceptScore W2043970086C2780739214 @default.
• W2043970086 hasConceptScore W2043970086C2908647359 @default.
• W2043970086 hasConceptScore W2043970086C45393284 @default.
• W2043970086 hasConceptScore W2043970086C500558357 @default.
• W2043970086 hasConceptScore W2043970086C71924100 @default.
• W2043970086 hasConceptScore W2043970086C99454951 @default.
• W2043970086 hasLocation W20439700861 @default.
• W2043970086 hasLocation W20439700862 @default.
• W2043970086 hasLocation W20439700863 @default.
• W2043970086 hasLocation W20439700864 @default.
• W2043970086 hasLocation W20439700865 @default.

• next